CXCL17 explained
| chemokine (C-X-C motif) ligand 7 |
| Symbol: | CXCL17 |
| Altsymbols: | SCYB17, VCC-1, DMC |
| Entrezgene: | 284340 |
| Refseq: | NM_198477 |
| Uniprot: | Q6UXB2 |
| Chromosome: | 19 |
| Arm: | q |
| Band: | 13.2 |
Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It is also known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).[1] [2] This chemokine is constitutively expressed in the lung.[2] The gene for human CXCL17 is located on chromosome 19.[2]
CXCL17 is an orphan chemokine with no known receptor.[3]
Receptor
The receptor for CXCL17 is likely to be a G protein-coupled receptor (GPCR).[4]
The GPCR GPR35 was thought to be a receptor of CXCL17.[5] Subsequent research has suggested that GPR35 is not a receptor for CXCL17.[6]
Notes and References
- Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R . VCC-1, a novel chemokine, promotes tumor growth . Biochemical and Biophysical Research Communications . 350 . 1 . 74–81 . November 2006 . 16989774 . 10.1016/j.bbrc.2006.08.194 .
- Pisabarro MT, Leung B, Kwong M, Corpuz R, Frantz GD, Chiang N, Vandlen R, Diehl LJ, Skelton N, Kim HS, Eaton D, Schmidt KN . Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods . Journal of Immunology . 176 . 4 . 2069–73 . February 2006 . 16455961 . 10.4049/jimmunol.176.4.2069 . free .
- Binti Mohd Amir NA, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE . Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35 . Journal of Immunology . 201 . 2 . 714–724 . June 2018 . 29875152 . 6036231 . 10.4049/jimmunol.1700884 .
- Burkhardt AM, Maravillas-Montero JL, Carnevale CD, Vilches-Cisneros N, Flores JP, Hevezi PA, Zlotnik A . CXCL17 is a major chemotactic factor for lung macrophages . Journal of Immunology . 193 . 3 . 1468–74 . August 2014 . 24973458 . 4142799 . 10.4049/jimmunol.1400551 .
- Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A . Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17 . Journal of Immunology . 194 . 1 . 29–33 . January 2015 . 25411203 . 4355404 . 10.4049/jimmunol.1401704 .
- Park SJ, Lee SJ, Nam SY, Im DS . GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17? . British Journal of Pharmacology . 175 . 1 . 154–161 . January 2018 . 29068046 . 5740256 . 10.1111/bph.14082 .
