CUMYL-PICA explained

CUMYL-PICA (SGT-56) is an indole-3-carboxamide based synthetic cannabinoid. It is the α,α-dimethylbenzyl analogue of SDB-006.^[1] It was briefly sold in New Zealand during 2013 as an ingredient of at the time legal synthetic cannabis products, but the product containing CUMYL-BICA and CUMYL-PICA was denied an interim licensing approval under the Psychoactive Substances regulatory scheme, due to reports of adverse events in consumers.^[2] CUMYL-PICA acts as an agonist for the cannabinoid receptors, with K_i values of 59.21 nM at CB₁ and 136.38 nM at CB₂ and EC₅₀ values of 11.98 nM at CB₁ and 16.2 nM at CB₂.^{[3] [4]}

See also

• 5F-CUMYL-PINACA
• 5F-SDB-006
• CUMYL-4CN-BINACA
• CUMYL-PINACA
• CUMYL-THPINACA
• SDB-006
• NNE1

Notes and References

1. Ametovski A, Macdonald C, Manning JJ, Haneef SA, Santiago M, Martin L, Sparkes E, Reckers A, Gerona RR, Connor M, Glass M, Banister SD . 6 . Exploring Stereochemical and Conformational Requirements at Cannabinoid Receptors for Synthetic Cannabinoids Related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA . ACS Chemical Neuroscience . 11 . 21 . 3672–3682 . November 2020 . 33054155 . 10.1021/acschemneuro.0c00591 . 222821806 .
2. Web site: The Risk Assessment Score Table. New Zealand Ministry of Health, 27 September 2013 . 2015-07-09 . https://web.archive.org/web/20140108103405/http://www.health.govt.nz/system/files/documents/pages/risk-assessment-score-table-27sept-13.pdf . 2014-01-08 . dead .
3. Gamage TF, Farquhar CE, Lefever TW, Marusich JA, Kevin RC, McGregor IS, Wiley JL, Thomas BF . 6 . Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA . The Journal of Pharmacology and Experimental Therapeutics . 365 . 2 . 437–446 . May 2018 . 29549157 . 5932312 . 10.1124/jpet.117.246983 .
4. Cannabinoid compounds . WO . 2014167530 . 11 April 2013 . Bowden MJ, Bernard WJ .