CUMYL-FUBINACA explained

CUMYL-FUBINACA (SGT-149) is an indazole-3-carboxamide based synthetic cannabinoid receptor agonist, with an EC₅₀ of 1.8nM for human CB₁ receptors and 23.7nM for human CB₂ receptors, giving it around 13x selectivity for CB₁.^{[1] [2] [3] [4]} It has been sold online as a designer drug.^[5]

See also

• AB-FUBINACA
• CUMYL-PINACA
• CUMYL-CBMINACA
• CUMYL-THPINACA
• MDMB-FUBINACA

Notes and References

1. Cannabinoid compounds . WO . 2014167530 . 11 April 2013 . Bowden MW, Williamson PB .
2. Longworth M, Banister SD, Boyd R, Kevin RC, Connor M, McGregor IS, Kassiou M . Pharmacology of Cumyl-Carboxamide Synthetic Cannabinoid New Psychoactive Substances (NPS) CUMYL-BICA, CUMYL-PICA, CUMYL-5F-PICA, CUMYL-5F-PINACA, and Their Analogues . ACS Chemical Neuroscience . 8 . 10 . 2159–2167 . October 2017 . 28792725 . 10.1021/acschemneuro.7b00267 .
3. Book: Banister SD, Connor M . New Psychoactive Substances . The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution . Handbook of Experimental Pharmacology . 2018 . 252 . 191–226 . 30105473 . 10.1007/164_2018_144 . 978-3-030-10560-0 .
4. Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G . 6 . Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex . Cell . 176 . 3 . 448–458.e12 . January 2019 . 30639101 . 10.1016/j.cell.2018.11.040 . 6461403 . free .
5. Thornton SL, Darracq MA, Gugelmann HM, Armenian P . Surface internet marketplace presence and availability of NPS sold as research chemicals: a snapshot study. . Toxicology Communications . 2019 . 3 . 1 . 67–74 . 10.1080/24734306.2019.1648067 . 202372196 . free .