CUMYL-4CN-BINACA explained

CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug.[1] [2] [3] [4] [5] [6] It is a potent agonist for cannabinoid receptors CB1 and CB2, with in vitro EC50 values of 0.58 nM and 6.12 nM, respectively.[7] In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects via the CB1 receptor, and anecdotal reports suggest it has an active dose of around 0.1 mg in humans.[8]

CUMYL-4CN-BINACA is metabolized to produce cyanide, raising concerns about liver toxicity.[6] There is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.[9]

See also

Notes and References

  1. Web site: 4-cyano CUMYL-BUTINACA . Cayman Chemical.
  2. Yeter O . Identification of the Synthetic Cannabinoid 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide (CUMYL-4CN-BINACA) in Plant Material and Quantification in Post-Mortem Blood Samples . Journal of Analytical Toxicology . 41 . 9 . 720–728 . November 2017 . 28977413 . 10.1002/dta.2248 .
  3. Staeheli SN, Poetzsch M, Veloso VP, Bovens M, Bissig C, Steuer AE, Kraemer T . In vitro metabolism of the synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA . Drug Testing and Analysis . 10 . 1 . 148–157 . January 2018 . 28885775 . 10.1002/dta.2298 .
  4. Bovens M, Bissig C, Staeheli SN, Poetzsch M, Pfeiffer B, Kraemer T . Structural characterization of the new synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA . Forensic Science International . 281 . 98–105 . December 2017 . 29125990 . 10.1016/j.forsciint.2017.10.020 .
  5. Arıkan Ölmez N, Kapucu H, Çallı Altun N, Eren B . Identification of the synthetic cannabinoid N-(2-phenyl-propan-2-yl)-1-(4-cyanobutyl)-1H-indazole-3-carboxamide (CUMYL-4CN-BINACA) in a herbal mixture product. Forensic Toxicology. January 2018. 1860-8965. 192–199. 36. 1. 10.1007/s11419-017-0372-y. 28058750.
  6. Åstrand A, Vikingsson S, Lindstedt D, Thelander G, Gréen H, Kronstrand R, Wohlfarth A . Metabolism study for CUMYL-4CN-BINACA in human hepatocytes and authentic urine specimens: Free cyanide is formed during the main metabolic pathway . Drug Testing and Analysis . 10 . 8 . 1270–1279 . March 2018 . 29577658 . 10.1002/dta.2373 .
  7. Kevin RC, Anderson L, McGregor IS, Boyd R, Manning JJ, Glass M, Connor M, Banister SD . 6 . CUMYL-4CN-BINACA Is an Efficacious and Potent Pro-Convulsant Synthetic Cannabinoid Receptor Agonist . Frontiers in Pharmacology . 10 . 595 . 2019 . 31191320 . 6549035 . 10.3389/fphar.2019.00595 . free .
  8. Web site: EMCDDA–Europol Joint Report on a new psychoactive substance: 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide (CUMYL-4CN-BINACA). www.emcdda.europa.eu.
  9. El Zahran T, Gerona R, Morgan BW, Pomerleau AC . A novel synthetic cannabinoid (Cumyl-4-cyano-BINACA) resulting in hyperthermia, rhabdomyolysis, and renal failure in a 29-year-old patient: it's not meningitis . Clinical Toxicology . 57 . 6 . 421–422 . June 2019 . 30442067 . 10.1080/15563650.2018.1534241 . 53566116 .

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