PARC (gene) explained

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.^{[1] [2] [3] [4]}

Interactions

PARC (gene) has been shown to interact with P53.

Further reading

• Ishikawa K, Nagase T, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 3 . 169–76 . 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
• Nakayama M, Kikuno R, Ohara O . Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Issaeva N, Bozko P, Enge M, etal . Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors . Nat. Med. . 10 . 12 . 1321–8 . 2005 . 15558054 . 10.1038/nm1146 . 82043 .
• Ko HS, Kim SW, Sriram SR, etal . Identification of far upstream element-binding protein-1 as an authentic Parkin substrate . J. Biol. Chem. . 281 . 24 . 16193–6 . 2006 . 16672220 . 10.1074/jbc.C600041200 . free .
• Kaustov L, Lukin J, Lemak A, etal . The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53 . J. Biol. Chem. . 282 . 15 . 11300–7 . 2007 . 17298945 . 10.1074/jbc.M611297200 . free .

Notes and References

1. Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA . PARC and CUL7 form atypical cullin RING ligase complexes . Cancer Res . 67 . 5 . 2006–14 . Mar 2007 . 17332328 . 10.1158/0008-5472.CAN-06-3241 . free .
2. Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA . The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1 . J Biol Chem . 274 . 43 . 30963–8 . Nov 1999 . 10521492 . 10.1074/jbc.274.43.30963 . free .
3. Nikolaev AY, Li M, Puskas N, Qin J, Gu W . Parc: a cytoplasmic anchor for p53 . Cell . 112 . 1 . 29–40 . Jan 2003 . 12526791 . 10.1016/S0092-8674(02)01255-2 . 18403676 . free .
4. Web site: Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein.