CTTNBP2 explained

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.^{[1] [2]}

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.

Interactions

CTTNBP2 has been shown to interact with:

• MOBKL3,
• PPP2CA,
• RP6-213H19.1,^[3]
• STRN3,^[3] and
• STRN.^[3]

Further reading

• Ohoka Y, Takai Y . Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 . Genes Cells . 3 . 9 . 603–12 . 1998 . 9813110 . 10.1046/j.1365-2443.1998.00216.x . 22413036 . free .
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 6 . 347–55 . 2000 . 11214970 . 10.1093/dnares/7.6.347 . free .
• Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D . Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei . J. Cell Biol. . 166 . 6 . 815–25 . 2004 . 15364959 . 2172106 . 10.1083/jcb.200404107 .

Notes and References

1. Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW . Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 . Genomics . 78 . 1–2 . 7–11 . Nov 2001 . 11707066 . 10.1006/geno.2001.6651 .
2. Web site: Entrez Gene: CTTNBP2 cortactin binding protein 2.
3. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Mol. Cell. Proteomics . 8 . 1 . 157–71 . Jan 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .