Cathepsin O Explained

Cathepsin O is an enzyme encoded by the CTSO gene in humans.^{[1] [2]}

Function

Cathepsin O is a cysteine cathepsin, a cysteine protease and a member of the cathepsin family. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases, and its proteolytic activity was abolished by an inhibitor of cysteine proteinase.^[2]

Further reading

• Shi GP, Chapman HA, Bhairi SM . Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. . FEBS Lett. . 357 . 2 . 129–34 . 1995 . 7805878 . 10.1016/0014-5793(94)01349-6 . 28099876 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Velasco G, Ferrando AA, Puente XS . Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues . J. Biol. Chem. . 269 . 43 . 27136–42 . 1994 . 10.1016/S0021-9258(18)47135-9 . 7929457 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Barbe L, Lundberg E, Oksvold P . Toward a confocal subcellular atlas of the human proteome . Mol. Cell. Proteomics . 7 . 3 . 499–508 . 2008 . 18029348 . 10.1074/mcp.M700325-MCP200 . etal. free .

External links

• The MEROPS online database for peptidases and their inhibitors: C01.035

Notes and References

1. Santamaría I, Pendás AM, Velasco G, López-Otín C . Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO) . Genomics . 53 . 2 . 231–4 . October 1998 . 9790772 . 10.1006/geno.1997.5180.
2. Web site: Entrez Gene: cathepsin O.