| catenin (cadherin-associated protein), delta 1 | |
| Hgncid: | 2515 |
| Symbol: | CTNND1 |
| Altsymbols: | CTNND |
| Entrezgene: | 1500 |
| Omim: | 601045 |
| Refseq: | NM_001331 |
| Uniprot: | O60716 |
| Chromosome: | 11 |
| Arm: | q |
| Band: | 12.1 |
| catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | |
| Hgncid: | 2516 |
| Symbol: | CTNND2 |
| Entrezgene: | 1501 |
| Omim: | 604275 |
| Refseq: | NM_001332 |
| Uniprot: | Q9UQB3 |
| Chromosome: | 5 |
| Arm: | p |
| Band: | 15.2 |
δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development.[1] Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]
While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor.[4]
Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.[5]