CTNNBIP1 explained

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.^{[1] [2]}

Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.^[1]

Further reading

• Yochum GS, Cleland R, Goodman RH . A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. . Mol. Cell. Biol. . 28 . 24 . 7368–79 . 2008 . 18852287 . 10.1128/MCB.00744-08 . 2593444.
• Sharma M, Henderson BR . IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. . J. Biol. Chem. . 282 . 11 . 8545–56 . 2007 . 17255093 . 10.1074/jbc.M610272200 . free .
• Takeda K, Kinoshita I, Shimizu Y . Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. . BMC Cancer . 8 . 328 . 2008 . 18992165 . 10.1186/1471-2407-8-328 . 2585585. etal . free .
• Wang W, Zhang X, Deng K . ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. . Cell Biochem. Funct. . 27 . 6 . 329–37 . 2009 . 19569129 . 10.1002/cbf.1576 . 36742591 . etal. free .
• Wang WJ, Tang W, Qiu ZY . Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages. . AI Zheng . 28 . 2 . 117–21 . 2009 . 19550115 .
• Reichel O, Mayr D, Durst F, Berghaus A . E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux. . Eur Arch Otorhinolaryngol . 265 . 8 . 937–42 . 2008 . 18183411 . 10.1007/s00405-007-0568-6 . 9080577 .
• Bazas VM, Lukyanova NY, Demash DV . Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer. . Exp. Oncol. . 30 . 3 . 235–9 . 2008 . 18806748 . etal.
• Kohler EM, Chandra SH, Behrens J, Schneikert J . Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. . Hum. Mol. Genet. . 18 . 2 . 213–26 . 2009 . 18854359 . 10.1093/hmg/ddn338 . free .
• Seo E, Jho EH . Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. . Biochem. Biophys. Res. Commun. . 357 . 1 . 81–6 . 2007 . 17418091 . 10.1016/j.bbrc.2007.03.117 .
• Ladeiro Y, Couchy G, Balabaud C . MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. . Hepatology . 47 . 6 . 1955–63 . 2008 . 18433021 . 10.1002/hep.22256 . 15190293 . etal.
• Zhang H, Xue Y . Wnt pathway is involved in advanced gastric carcinoma. . Hepatogastroenterology . 55 . 84 . 1126–30 . 2008. 18705344 .
• Wang HX, Tekpetey FR, Kidder GM . Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. . Mol. Hum. Reprod. . 15 . 1 . 11–7 . 2009 . 19038973 . 10.1093/molehr/gan070 . free .
• Matono H, Oda Y, Nakamori M . Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. . Hum. Pathol. . 39 . 12 . 1802–8 . 2008 . 18715618 . 10.1016/j.humpath.2008.05.005 . etal.
• Wang L, O'Leary H, Fortney J, Gibson LF . Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. . Blood . 110 . 9 . 3334–44 . 2007 . 17638851 . 10.1182/blood-2007-01-068122 . 2200915.
• von Koch CS, Gulati M, Aldape K, Berger MS . Familial medulloblastoma: case report of one family and review of the literature. . Neurosurgery . 51 . 1 . 227–33; discussion 233 . 2002 . 12182422 . 10.1097/00006123-200207000-00035. 21293611 .
• Wang L, Li H, Zhang Y . HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. . Int. J. Cancer . 124 . 7 . 1526–34 . 2009 . 19089909 . 10.1002/ijc.24072 . 2667231. etal.
• Chen Y, Bodles AM . Amyloid precursor protein modulates beta-catenin degradation. . Journal of Neuroinflammation . 4 . 29 . 2007 . 18070361 . 10.1186/1742-2094-4-29 . 2231348 . free .
• Kastritis E, Murray S, Kyriakou F . Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. . Int. J. Cancer . 124 . 1 . 103–8 . 2009 . 18844223 . 10.1002/ijc.23917 . etal. free .
• Turbiner J, Moreno-Bueno G, Dahiya S . Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen. . Mod. Pathol. . 21 . 8 . 925–36 . 2008 . 18500270 . 10.1038/modpathol.2008.49 . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948. etal.

Notes and References

1. Web site: Entrez Gene: catenin.
2. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T . Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein . Genes Dev. . 14 . 14 . 1741–9 . July 2000 . 10.1101/gad.14.14.1741 . 10898789 . 316784 .