CTF8 explained

Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene.^{[1] [2]}

This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair.

This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X.

Further reading

• Mayer ML, Gygi SP, Aebersold R, Hieter P . Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae . Mol. Cell . 7 . 5 . 959–70 . 2001 . 11389843 . 10.1016/S1097-2765(01)00254-4 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Sun M . A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors . Mol. Med. . 8 . 10 . 655–63 . 2004 . 12477976 . 10.1007/BF03402176. 2039945 . vanc. Ma L . Xu L . 3 . Li . J . Zhang . W . Petrovics . G . Makarem . M . Sesterhenn . I . Zhang . M .
• Bermudez VP . The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA . Proc. Natl. Acad. Sci. U.S.A. . 100 . 18 . 10237–42 . 2003 . 12930902 . 10.1073/pnas.1434308100 . 193545 . vanc. Maniwa Y . Tappin I . 3 . Ozato . K . Yokomori . K . Hurwitz . J . 2003PNAS..10010237B . free .
• Brandenberger R . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . vanc. Wei H . Zhang S . 3 . Lei . Shirley . Murage . Jaji . Fisk . Gregory J . Li . Yan . Xu . Chunhui . Fang . Rixun . 27764390 .
• Suzuki Y . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . vanc. Yamashita R . Shirota M . 3 . Sakakibara . Y . Chiba . J . Mizushima-Sugano . J . Nakai . K . Sugano . S .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. Merkle CJ, Karnitz LM, Henry-Sanchez JT, Chen J . Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment . J Biol Chem . 278 . 32 . 30051–6 . Aug 2003 . 12766176 . 10.1074/jbc.M211591200 . free .
2. Web site: Entrez Gene: CTF8 chromosome transmission fidelity factor 8 homolog (S. cerevisiae).