CTDSPL explained

CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.^{[1] [2] [3]}

Interactions

CTDSPL has been shown to interact with SNAI1.^[4]

Further reading

• O'Keeffe B, Fong Y, Chen D . Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. . J. Biol. Chem. . 275 . 1 . 279–87 . 2000 . 10617616 . 10.1074/jbc.275.1.279 . etal. free.
• Kim JB, Sharp PA . Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase. . J. Biol. Chem. . 276 . 15 . 12317–23 . 2001 . 11145967 . 10.1074/jbc.M010908200 . free .
• Ramanathan Y, Rajpara SM, Reza SM . Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. . J. Biol. Chem. . 276 . 14 . 10913–20 . 2001 . 11278802 . 10.1074/jbc.M010975200 . etal. free .
• Zhou M, Nekhai S, Bharucha DC . TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription. . J. Biol. Chem. . 276 . 48 . 44633–40 . 2002 . 11572868 . 10.1074/jbc.M107466200 . etal. free .
• Lin X, Taube R, Fujinaga K, Peterlin BM . P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. . J. Biol. Chem. . 277 . 19 . 16873–8 . 2002 . 11884399 . 10.1074/jbc.M200117200 . free .
• Kim YK, Bourgeois CF, Isel C . Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. . Mol. Cell. Biol. . 22 . 13 . 4622–37 . 2002 . 12052871 . 10.1128/MCB.22.13.4622-4637.2002 . 133925 . etal.
• Yeo M, Lin PS, Dahmus ME, Gill GN . A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. . J. Biol. Chem. . 278 . 28 . 26078–85 . 2003 . 12721286 . 10.1074/jbc.M301791200 . free .
• Pinhero R, Liaw P, Bertens K, Yankulov K . Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II. . Eur. J. Biochem. . 271 . 5 . 1004–14 . 2004 . 15009212 . 10.1111/j.1432-1033.2004.04002.x . free .
• Kashuba VI, Li J, Wang F . RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 14 . 4906–11 . 2004 . 15051889 . 10.1073/pnas.0401238101 . 387347 . etal. 2004PNAS..101.4906K . free .

Notes and References

1. Ishikawa S, Kai M, Tamari M, Takei Y, Takeuchi K, Bandou H, Yamane Y, Ogawa M, Nakamura Y . Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line . DNA Res . 4 . 1 . 35–43 . Aug 1997 . 9179494 . 10.1093/dnares/4.1.35 . free .
2. Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER . An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies . Cancer Res . 63 . 2 . 404–12 . Jan 2003 . 12543795 .
3. Web site: Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like.
4. Wu . Yadi . Evers B Mark . Zhou Binhua P . Jan 2009 . Small C-terminal domain phosphatase enhances snail activity through dephosphorylation . J. Biol. Chem. . 284 . 1 . 640–8 . United States. 0021-9258. 19004823 . 10.1074/jbc.M806916200 . 2610500 . free .