CSRP2 explained

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.^{[1] [2] [3]}

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.

Further reading

• Jain MK . Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells . J. Biol. Chem. . 271 . 17 . 10194–9 . 1996 . 8626582 . 10.1074/jbc.271.17.10194 . Fujita KP . Hsieh CM . Endege . WO . Sibinga . NE . Yet . SF . Kashiki . S . Lee . WS . Perrella . MA . free.
• Karim MA . Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3 . Genomics . 31 . 2 . 167–76 . 1997 . 8824798 . 10.1006/geno.1996.0028 . Ohta K . Egashira M . Jinno . Yoshihiro . Niikawa . Norio . Matsuda . Ichiro . Indo . Yasuhiro .
• Weiskirchen R, Gressner AM . The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP) . Biochem. Biophys. Res. Commun. . 274 . 3 . 655–63 . 2000 . 10924333 . 10.1006/bbrc.2000.3187 .
• Weiskirchen R . LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1 . Biochem. J. . 359 . Pt 3 . 485–96 . 2001 . 11672422 . 10.1042/0264-6021:3590485 . 1222169 . Moser M . Weiskirchen S . Erdel . Martin . Dahmen . Sandra . Buettner . Reinhard . Gressner . Axel M. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wang M, Hu Y, Shima I, Stearns ME . IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines . Cancer Biol. Ther. . 1 . 5 . 556–63 . 2003 . 12496489 . 10.4161/cbt.1.5.222. free .
• Stearns ME, Wang M, Hu Y, Garcia FU . Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines . Mol. Cancer Res. . 1 . 9 . 631–42 . 2004 . 12861049 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC . The cysteine-rich protein family of highly related LIM domain proteins . J Biol Chem . 270 . 48 . 28946–54 . Jan 1996 . 7499425 . 10.1074/jbc.270.48.28946 . free .
2. Weiskirchen R, Erdel M, Utermann G, Bister K . Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2 . Genomics . 44 . 1 . 83–93 . Nov 1997 . 9286703 . 10.1006/geno.1997.4855 .
3. Web site: Entrez Gene: CSRP2 cysteine and glycine-rich protein 2.