CSRP1 explained

Cysteine and glycine-rich protein 1 is a protein that in humans is encoded by the CSRP1 gene.^{[1] [2] [3]}

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3.

Further reading

• Weiskirchen R, Günther K . The CRP/MLP/TLP family of LIM domain proteins: acting by connecting . BioEssays . 25 . 2 . 152–62 . 2003 . 12539241 . 10.1002/bies.10226 . 21364125 .
• Wang X, Lee G, Liebhaber SA, Cooke NE . Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc . J. Biol. Chem. . 267 . 13 . 9176–84 . 1992 . 10.1016/S0021-9258(19)50405-7 . 1374386 . free .
• Wang X, Ray K, Szpirer J . Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism . Genomics . 14 . 2 . 391–7 . 1992 . 1385304 . 10.1016/S0888-7543(05)80231-9 . etal. free .
• Feuerstein R, Wang X, Song D . The LIM/double zinc-finger motif functions as a protein dimerization domain . Proc. Natl. Acad. Sci. U.S.A. . 91 . 22 . 10655–9 . 1994 . 7938009 . 10.1073/pnas.91.22.10655 . 45080 . 1994PNAS...9110655F . etal. free .
• Dubé JY, Chapdelaine P, Trahan PL . Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate . Arch. Androl. . 40 . 2 . 109–15 . 1998 . 9507743 . 10.3109/01485019808987933 . etal.
• Harper BD, Beckerle MC, Pomiès P . Fine mapping of the alpha-actinin binding site within cysteine-rich protein . Biochem. J. . 350 Pt 1 . Pt 1. 269–74 . 2001 . 10926853 . 10.1042/0264-6021:3500269. 1221251 .
• Andersen JS, Lyon CE, Fox AH . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . etal. free . 2002CBio...12....1A .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Hirasawa Y, Arai M, Imazeki F . Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma . Oncology . 71 . 1–2 . 77–85 . 2007 . 17341888 . 10.1159/000100475 . 40174270 . etal.
• Wang Q, Williamson M, Bott S . Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer . Oncogene . 26 . 45 . 6560–5 . 2007 . 17486081 . 10.1038/sj.onc.1210472 . etal. 19222997 .

Notes and References

1. Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE . Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif . Nucleic Acids Res . 18 . 13 . 3871–9 . Aug 1990 . 2115670 . 331088 . 10.1093/nar/18.13.3871 .
2. Erdel M, Weiskirchen R . Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization . Cytogenet Cell Genet . 83 . 1–2 . 10–1 . Mar 1999 . 9925910 . 10.1159/000015152 . 28018584 .
3. Web site: Entrez Gene: CSRP1 cysteine and glycine-rich protein 1.