CSN1S1 explained

Alpha-S1-casein is a protein that in humans is encoded by the CSN1S1 gene.^{[1] [2] [3]}

Interactions

CSN1S1 has been shown to interact with SAP130.^[4]

Further reading

• Takahashi M, Tomizawa K, Sato K . A novel tau-tubulin kinase from bovine brain. . FEBS Lett. . 372 . 1 . 59–64 . 1995 . 7556643 . 10.1016/0014-5793(95)00955-9 . 42295269 . etal. free .
• Creasy CL, Chernoff J . Cloning and characterization of a human protein kinase with homology to Ste20. . J. Biol. Chem. . 270 . 37 . 21695–700 . 1995 . 7665586 . 10.1074/jbc.270.37.21695 . free .
• Chen CS, Bejcek BE, Kersey JH . A mapping study of 13 genes on human chromosome bands 4q11→q25. . Cytogenet. Cell Genet. . 69 . 3–4 . 260–5 . 1995 . 7698025 . 10.1159/000133976 .
• Cavaletto M, Cantisani A, Giuffrida G . Human alpha S1-casein like protein: purification and N-terminal sequence determination. . Biol. Chem. Hoppe-Seyler . 375 . 2 . 149–51 . 1994 . 8192860 . 10.1515/bchm3.1994.375.2.149 . etal.
• Murakami K, Lagarde M, Yuki Y . Identification of minor proteins of human colostrum and mature milk by two-dimensional electrophoresis. . Electrophoresis . 19 . 14 . 2521–7 . 1999 . 9820977 . 10.1002/elps.1150191427 . 22786503 .
• Silljé HH, Takahashi K, Tanaka K . Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. . EMBO J. . 18 . 20 . 5691–702 . 1999 . 10523312 . 10.1093/emboj/18.20.5691 . 1171636 . etal.
• Menegay HJ, Myers MP, Moeslein FM, Landreth GE . Biochemical characterization and localization of the dual specificity kinase CLK1. . 113 . J. Cell Sci. . (Pt 18) . 3241–53 . 2000 . 18 . 10.1242/jcs.113.18.3241 . 10954422 .
• Gray CW, Ward RV, Karran E . Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. . Eur. J. Biochem. . 267 . 18 . 5699–710 . 2000 . 10971580 . 10.1046/j.1432-1327.2000.01589.x . etal. free .
• Harrington JJ, Sherf B, Rundlett S . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 . etal.
• Kashiwaba M, Katsura K, Ohnishi M . A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. . FEBS Lett. . 538 . 1–3 . 197–202 . 2003 . 12633878 . 10.1016/S0014-5793(03)00153-4 . 32830511 . etal. free .
• Xu K, Ling MT, Wang X, Wong YC . Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia. . Prostate Cancer Prostatic Dis. . 9 . 3 . 293–7 . 2007 . 16683014 . 10.1038/sj.pcan.4500872 . 11411039 .

Notes and References

1. Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M . Genomic organization and chromosomal localization of the human casein gene family . Hum Genet . 99 . 3 . 368–73 . Mar 1997 . 9050925 . 10.1007/s004390050374 . 8299892 .
2. Johnsen LB, Rasmussen LK, Petersen TE, Berglund L . Characterization of three types of human alpha s1-casein mRNA transcripts . 309 . Biochem J . (Pt 1) . 237–42 . Aug 1995 . Pt 1 . 7619062 . 1135825 . 10.1042/bj3090237.
3. Web site: Entrez Gene: CSN1S1 casein alpha s1.
4. Menon . Suchithra . Tsuge Tomohiko . Dohmae Naoshi . Takio Koji . Wei Ning . 2008. Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome . BMC Biochem. . 9. 1 . 18173839 . 10.1186/1471-2091-9-1 . 2265268 . free .