| Season Number: | 4 |
| Bgcolour: |
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| Starring: | David Caruso Emily Procter Adam Rodriguez Khandi Alexander Jonathan Togo |
| Num Episodes: | 25 |
| Network: | CBS |
| Episode List: | List of CSI: Miami episodes |
The fourth season of premiered on CBS on September 19, 2005 and ended May 22, 2006. The series stars David Caruso and Emily Procter.
With a mole in their midst, Horatio and Calleigh head a team of elite Crime Scene Investigators as they enter their most challenging season yet. Under the roof of a state-of-the-art redesigned crime lab, the dynamic duo investigate a series of crimes including a night-club murder, the death of a pool boy, a cold case rape, and a murder with a double-jeopardy clause, all whilst under the scrutiny of an anonymous mole, and facing a series of cases that threaten the team. With Alexx accused of murdering a child molester, Horatio accused of murdering an innocent woman, Wolfe facing the loss of his eye, and Mac Taylor joining the team when a prisoner transfer goes awry, it's ultimately Delko who faces the greatest loss: his sister who was to marry Horatio is gunned down by the Mala Noche gang in an attack that will begin a narrative recurring throughout the next several seasons.