CRYZL1 explained

Quinone oxidoreductase-like protein 1 is an enzyme that in humans is encoded by the CRYZL1 gene.^{[1] [2]}

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.

Further reading

• Mount SM . Genomic Sequence, Splicing, and Gene Annotation . Am. J. Hum. Genet. . 67 . 4 . 788–92 . 2000 . 10986039 . 10.1086/303098 . 1287883 .
• Hattori M . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . vanc. Fujiyama A . Taylor TD . 3 . Taylor . T. D. . Watanabe . H. . Yada . T. . Park . H.-S. . Toyoda . A. . Ishii . K. . 2000Natur.405..311H . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Hu YH . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . vanc. Warnatz HJ . Vanhecke D . 3 . Wagner . Florian . Fiebitz . Andrea . Thamm . Sabine . Kahlem . Pascal . Lehrach . Hans . Yaspo . Marie-Laure . free .
• Fernández MR . Human and yeast zeta-crystallins bind AU-rich elements in RNA . Cell. Mol. Life Sci. . 64 . 11 . 1419–27 . 2007 . 17497241 . 10.1007/s00018-007-7091-1 . vanc. Porté S . Crosas E . 3 . Barberà . N. . Farrés . J. . Biosca . J. A. . Parés . X. . 2165411 . 11136237.

Notes and References

1. Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J . Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1 . Genomics . 57 . 1 . 156–9 . Jun 1999 . 10191096 . 10.1006/geno.1998.5714 .
2. Web site: Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1.