CRTC3 explained
CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[1] [2] [3]
This gene has been shown to be linked to weight gain.[4]
Further reading
- Hishiki T, Ohshima T, Ego T, Shimotohno K . BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3 . The Journal of Biological Chemistry . 282 . 39 . 28335–43 . Sep 2007 . 17644518 . 10.1074/jbc.M702656200 . free .
- Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC . Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells . Proceedings of the National Academy of Sciences of the United States of America . 103 . 39 . 14379–84 . Sep 2006 . 16980408 . 1569674 . 10.1073/pnas.0606714103 . 2006PNAS..10314379W . free .
- Koga H, Ohshima T, Shimotohno K . Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3 . The Journal of Biological Chemistry . 279 . 51 . 52978–83 . December 2004 . 15466468 . 10.1074/jbc.M409021200 . free .
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . free . 2004CBio...14.1436J .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
Notes and References
- Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M . TORCs: transducers of regulated CREB activity . Molecular Cell . 12 . 2 . 413–23 . Aug 2003 . 14536081 . 10.1016/j.molcel.2003.08.013 . free .
- Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA . Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells . Proceedings of the National Academy of Sciences of the United States of America . 100 . 21 . 12147–52 . Oct 2003 . 14506290 . 218727 . 10.1073/pnas.1932773100 . free .
- Web site: Entrez Gene: CRTC3 CREB regulated transcription coactivator 3.
- Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M . CRTC3 links catecholamine signalling to energy balance . Nature . 468 . 7326 . 933–939 . Dec 2010 . 21164481 . 10.1038/nature09564 . 3025711. 2010Natur.468..933S .
