CRLF3 explained

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.^[1]

Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.^[2]

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.^{[3] [4]}

Further reading

• Visser R, Koelma N, Vijfhuizen L, van der Wielen MJ, Kant SG, Breuning MH, Wit JM, Losekoot M . 6 . RNF135 mutations are not present in patients with Sotos syndrome-like features . American Journal of Medical Genetics. Part A . 149A . 4 . 806–8 . February 2009 . 19291764 . 10.1002/ajmg.a.32694 . 10349510 .
• Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K . 6 . Many sequence variants affecting diversity of adult human height . Nature Genetics . 40 . 5 . 609–15 . May 2008 . 18391951 . 10.1038/ng.122 . 3005450 .
• Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF . 6 . The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature . BMC Medical Genetics . 11 . 96 . June 2010 . 20546612 . 2894790 . 10.1186/1471-2350-11-96 . free .
• Yang F, Xu YP, Li J, Duan SS, Fu YJ, Zhang Y, Zhao Y, Qiao WT, Chen QM, Geng YQ, Che CY, Cao YL, Wang Y, Zhang L, Long L, He J, Cui QC, Chen SC, Wang SH, Liu L . 6 . Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression . The International Journal of Biochemistry & Cell Biology . 41 . 11 . 2240–50 . November 2009 . 19427400 . 10.1016/j.biocel.2009.04.022 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G . 6 . Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot" . PLOS Genetics . 6 . 7 . e1001016 . July 2010 . 20628624 . 2900295 . 10.1371/journal.pgen.1001016 . free .
• Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H . 6 . Toward a confocal subcellular atlas of the human proteome . Molecular & Cellular Proteomics . 7 . 3 . 499–508 . March 2008 . 18029348 . 10.1074/mcp.M700325-MCP200 . free .
• Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, Burn J, Huson S, Josifova D, Lacombe D, Malik M, Mansour S, Reid E, Cormier-Daire V, Cole T, Rahman N . 6 . Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth . Nature Genetics . 39 . 8 . 963–5 . August 2007 . 17632510 . 10.1038/ng2083 . 35797973 .

Notes and References

1. Web site: Entrez Gene: cytokine receptor-like factor 3.
2. Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, Bucher G, Ehrenreich H, Heinrich R . 6 . The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor . en . Frontiers in Molecular Neuroscience . 10 . 223 . 2017 . 28769759 . 5509957 . 10.3389/fnmol.2017.00223 . free .
3. Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, Massih B, Göpfert MC . 6 . 2019 . The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts . Frontiers in Molecular Neuroscience . 12 . 251 . 10.3389/fnmol.2019.00251 . 31680856 . 6797617 . free .
4. Liongue C, Ward AC . Evolution of Class I cytokine receptors . BMC Evolutionary Biology . 7 . 1 . 120 . July 2007 . 17640376 . 1963337 . 10.1186/1471-2148-7-120 . free . 2007BMCEE...7..120L .