CRLF2 explained

Cytokine receptor-like factor 2 (also known as TSLP receptor, TSLP-R) is a protein that in humans is encoded by the CRLF2 gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).^{[1] [2] [3]}

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM]^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Hiroyama T, Iwama A, Morita Y . 38299268 . Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells . Biochem. Biophys. Res. Commun. . 272 . 1 . 224–9 . 2000 . 10872831 . 10.1006/bbrc.2000.2764 . etal. 2241/1571 . free .
• Reche PA, Soumelis V, Gorman DM . Human thymic stromal lymphopoietin preferentially stimulates myeloid cells . J. Immunol. . 167 . 1 . 336–43 . 2001 . 11418668 . 10.4049/jimmunol.167.1.336. etal. free .
• Blagoev B, Nielsen MM, Angrist M . Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene . Gene . 284 . 1–2 . 161–8 . 2002 . 11891057 . 10.1016/S0378-1119(02)00380-3 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Rochman I, Watanabe N, Arima K . Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells . J. Immunol. . 178 . 11 . 6720–4 . 2007 . 17513717 . 10.4049/jimmunol.178.11.6720. etal. free .

Notes and References

1. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X . Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes . Biochem Biophys Res Commun . 281 . 4 . 878–83 . Mar 2001 . 11237741 . 10.1006/bbrc.2001.4432 .
2. Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T . Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR . Cytogenet Cell Genet . 93 . 1–2 . 23–5 . Jul 2001 . 11474172 . 10.1159/000056941 . 83630087 .
3. Web site: Entrez Gene: CRLF2 cytokine receptor-like factor 2.