CRIPT explained

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.^{[1] [2] [3] [4] [5]}

Interactions

CRIPT has been shown to interact with DLG3.^[6]

Further reading

• Zhang QH, Ye M, Wu XY . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Lim IA, Hall DD, Hell JW . Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. . J. Biol. Chem. . 277 . 24 . 21697–711 . 2002 . 11937501 . 10.1074/jbc.M112339200 . free .
• Cai C, Coleman SK, Niemi K, Keinänen K . Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. . J. Biol. Chem. . 277 . 35 . 31484–90 . 2002 . 12070168 . 10.1074/jbc.M204354200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G . Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. . J. Am. Chem. Soc. . 128 . 17 . 5913–22 . 2007 . 16637659 . 10.1021/ja060943h . 2533859 .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .

Notes and References

1. Fukunaga Y, Matsubara M, Nagai R, Miyazawa A . The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins . J Biochem . 138 . 2 . 177–82 . Aug 2005 . 16091592 . 10.1093/jb/mvi107 .
2. Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF . The PDZ1 domain of SAP90. Characterization of structure and binding . J Biol Chem . 277 . 9 . 6967–73 . Feb 2002 . 11744724 . 10.1074/jbc.M109453200 . free .
3. Passafaro M, Sala C, Niethammer M, Sheng M . Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95 . Nat Neurosci . 2 . 12 . 1063–9 . Jan 2000 . 10570482 . 10.1038/15990 . 8145832 .
4. Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M . CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90 . Neuron . 20 . 4 . 693–707 . Jun 1998 . 9581762 . 10.1016/S0896-6273(00)81009-0 . 16068361 . free .
5. Web site: Entrez Gene: CRIPT cysteine-rich PDZ-binding protein.
6. Lim . Indra Adi . Hall Duane D . Hell Johannes W . Jun 2002 . Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 . J. Biol. Chem. . 277 . 24 . 21697–711 . United States. 0021-9258. 11937501 . 10.1074/jbc.M112339200 . free .