CRIP2 explained

Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.^{[1] [2] [3] [4]}

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . Akira . Sugano . Sumio .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• van Ham M . Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL . Genes Cells . 8 . 7 . 631–44 . 2004 . 12839623 . 10.1046/j.1365-2443.2003.00660.x . vanc. Croes H . Schepens J . 3 . Fransen . Jack . Wieringa . Be . Hendriks . Wiljan . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . free .

Notes and References

1. Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY . A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation . Biochem Mol Biol Int . 39 . 4 . 747–54 . Feb 1997 . 10.1080/15216549600201831 . 8843343 . 25981657 . free .
2. Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y . Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3 . Genomics . 31 . 2 . 167–76 . January 1996 . 8824798 . 10.1006/geno.1996.0028 .
3. Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD . Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle . J Biol Chem . 275 . 8 . 5504–11 . Mar 2000 . 10681529 . 10.1074/jbc.275.8.5504 . free .
4. Web site: Entrez Gene: CRIP2 cysteine-rich protein 2.
5. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ . Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors . Dev. Cell . 4 . 1 . 107–18 . January 2003 . 12530967 . 10.1016/S1534-5807(02)00396-9. free .