CRELD1 explained

Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.^{[1] [2]}

Function

Epidermal growth factor (EGF)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.^[3]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Robinson SW, Morris CD, Goldmuntz E . Missense Mutations in CRELD1 Are Associated with Cardiac Atrioventricular Septal Defects . Am. J. Hum. Genet. . 72 . 4 . 1047–52 . 2003 . 12632326 . 10.1086/374319 . 1180336 . etal.
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Zatyka M, Priestley M, Ladusans EJ . Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2) . Clin. Genet. . 67 . 6 . 526–8 . 2005 . 15857420 . 10.1111/j.1399-0004.2005.00435.x . 31199574 . etal.
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.

Notes and References

1. Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER . Detailed mapping of a congenital heart disease gene in chromosome 3p25 . J Med Genet . 37 . 8 . 581–7 . Sep 2000 . 10922384 . 1734659 . 10.1136/jmg.37.8.581 .
2. Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL . Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins . Gene . 293 . 1–2 . 47–57 . Jul 2002 . 12137942 . 10.1016/S0378-1119(02)00696-0 . matricellular protein .
3. Web site: Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1.