CREG1 explained

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.^{[1] [2]}

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.

Further reading

• Veal E, Groisman R, Eisenstein M, Gill G . The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells . Oncogene . 19 . 17 . 2120–8 . 2000 . 10815803 . 10.1038/sj.onc.1203529 . free .
• Jiang LQ, Wen SJ, Wang HY, Chen LY . Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system . Hypertens. Res. . 25 . 4 . 647–52 . 2003 . 12358155 . 10.1291/hypres.25.647 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Di Bacco A, Gill G . The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor . Oncogene . 22 . 35 . 5436–45 . 2003 . 12934103 . 10.1038/sj.onc.1206670 . free .
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .
• Sacher M, Di Bacco A, Lunin VV . The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation . Proc. Natl. Acad. Sci. U.S.A. . 102 . 51 . 18326–31 . 2006 . 16344469 . 10.1073/pnas.0505071102 . 1317909 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Veal E, Eisenstein M, Tseng ZH, Gill G . A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F . Mol Cell Biol . 18 . 9 . 5032–41 . Sep 1998 . 9710587 . 109088 . 10.1128/mcb.18.9.5032.
2. Web site: Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1.