CREBL1 explained

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.^{[1] [2]}

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Further reading

• Bristow J, Tee MK, Gitelman SE . Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. . J. Cell Biol. . 122 . 1 . 265–78 . 1993 . 7686164 . 10.1083/jcb.122.1.265 . 2119596 . etal.
• Min J, Shukla H, Kozono H . A novel Creb family gene telomeric of HLA-DRA in the HLA complex. . Genomics . 30 . 2 . 149–56 . 1996 . 8586413 . 10.1006/geno.1995.9891 . etal. free .
• Khanna A, Campbell RD . The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. . 319 . Biochem. J. . (Pt 1) . 81–9 . 1996 . Pt 1 . 8870652 . 10.1042/bj3190081. 1217738 .
• Speek M, Barry F, Miller WL . Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. . Hum. Mol. Genet. . 5 . 11 . 1749–58 . 1997 . 8923003 . 10.1093/hmg/5.11.1749 . free .
• Swanson DJ, Adachi M, Lewis EJ . The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. . J. Biol. Chem. . 275 . 4 . 2911–23 . 2000 . 10644760 . 10.1074/jbc.275.4.2911 . free .
• Yoshida H, Okada T, Haze K . Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. . Mol. Cell. Biol. . 21 . 4 . 1239–48 . 2001 . 11158310 . 10.1128/MCB.21.4.1239-1248.2001 . 99577 . etal.
• Ye J, Rawson RB, Komuro R . ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. . Mol. Cell . 6 . 6 . 1355–64 . 2001 . 11163209 . 10.1016/S1097-2765(00)00133-7 . etal. free .
• Haze K, Okada T, Yoshida H . Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. . Biochem. J. . 355 . Pt 1 . 19–28 . 2001 . 11256944 . 10.1042/0264-6021:3550019 . 1221707 . etal.
• Tong WY, Nagano-Fujii M, Hidajat R . Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta. . Biochem. Biophys. Res. Commun. . 299 . 3 . 366–72 . 2003 . 12445808 . 10.1016/S0006-291X(02)02638-4 . etal . 2020-09-05 . 2020-07-12 . https://web.archive.org/web/20200712155032/http://www.lib.kobe-u.ac.jp/repository/90000063.pdf . dead .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Okada T, Haze K, Nadanaka S . A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. . J. Biol. Chem. . 278 . 33 . 31024–32 . 2003 . 12782636 . 10.1074/jbc.M300923200 . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Xie T, Rowen L, Aguado B . Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. . Genome Res. . 13 . 12 . 2621–36 . 2004 . 14656967 . 10.1101/gr.1736803 . 403804 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Web site: Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1.
2. Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K . Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response . Biochem. J. . 355 . Pt 1 . 19–28 . April 2001 . 11256944 . 1221707 . 10.1042/0264-6021:3550019.