CREB5 explained

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.^{[1] [2] [3]}

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,^[4] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

Further reading

• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . vanc. Fulton RS . Fulton LA . 3 . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Harrington JJ . Creation of genome-wide protein expression libraries using random activation of gene expression . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . vanc. Sherf B . Rundlett S . 3 . Jackson . P. David . Perry . Rob . Cain . Scott . Leventhal . Christina . Thornton . Mark . Ramachandran . Rakesh . 25064683 .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097 . . free .

Notes and References

1. Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S . Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA . Oncogene . 8 . 10 . 2749–58 . Oct 1993 . 8378084 .
2. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S . Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 . J Biol Chem . 268 . 6 . 4259–66 . Mar 1993 . 10.1016/S0021-9258(18)53604-8 . 8440710 . free .
3. Web site: Entrez Gene: CREB5 cAMP responsive element binding protein 5.
4. Book: Cumulated Index Medicus. 1993. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. en.