RCP9 explained

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.^{[1] [2] [3] [4]}

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Yallampalli C, Chauhan M, Thota CS, etal . Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity . Trends Endocrinol. Metab. . 13 . 6 . 263–9 . 2003 . 12128288 . 10.1016/s1043-2760(02)00563-5. 28476322 .
• Evans BN, Rosenblatt MI, Mnayer LO, etal . CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors . J. Biol. Chem. . 275 . 40 . 31438–43 . 2000 . 10903324 . 10.1074/jbc.M005604200 . free .
• Prado MA, Evans-Bain B, Oliver KR, Dickerson IM . The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction . Peptides . 22 . 11 . 1773–81 . 2002 . 11754963 . 10.1016/S0196-9781(01)00517-4 . 37139980 .
• Moreno MJ, Terrón JA, Stanimirovic DB, etal . Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture . Neuropharmacology . 42 . 2 . 270–80 . 2002 . 11804624 . 10.1016/S0028-3908(01)00176-9 . 45479910 .
• Harzenetter MD, Keller U, Beer S, etal . Regulation and function of the CGRP receptor complex in human granulopoiesis . Exp. Hematol. . 30 . 4 . 306–12 . 2002 . 11937264 . 10.1016/S0301-472X(02)00772-5 . free .
• Hu P, Wu S, Sun Y, etal . Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits . Mol. Cell. Biol. . 22 . 22 . 8044–55 . 2002 . 12391170 . 10.1128/MCB.22.22.8044-8055.2002 . 134740 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hasbak P, Saetrum Opgaard O, Eskesen K, etal . Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist . J. Pharmacol. Exp. Ther. . 304 . 1 . 326–33 . 2003 . 12490608 . 10.1124/jpet.102.037754 . 14045615 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Zuccarello D, Morini E, Douzgou S, etal . Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism . J. Endocrinol. Invest. . 27 . 8 . 760–4 . 2005 . 15636430 . 10.1007/bf03347519. 19253890 .
• Krämer HH, Schmidt K, Leis S, etal . Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin . Peptides . 27 . 4 . 917–20 . 2006 . 16406141 . 10.1016/j.peptides.2005.08.007 . 24455456 .

Notes and References

1. Luebke AE, Dahl GP, Roos BA, Dickerson IM . Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay . Proc Natl Acad Sci U S A . 93 . 8 . 3455–60 . Jun 1996 . 8622957 . 39630 . 10.1073/pnas.93.8.3455 . free . 1996PNAS...93.3455L .
2. Balkan W, Oates EL, Howard GA, Roos BA . Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein . Endocrinology . 140 . 3 . 1459–69 . Mar 1999 . 10067875 . 10.1210/endo.140.3.6541 . free .
3. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C . An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP . Mol Cell Biol . 23 . 1 . 195–205 . Dec 2002 . 12482973 . 140662 . 10.1128/MCB.23.1.195-205.2003 .
4. Web site: Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein.