CRB3 explained
Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.[1]
Function
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Further reading
- Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A . hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells . The Journal of Biological Chemistry . 277 . 28 . 25408–15 . Jul 2002 . 11964389 . 10.1074/jbc.M202196200 . free .
- Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B . Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1) . Gene . 302 . 1–2 . 21–9 . Jan 2003 . 12527193 . 10.1016/S0378111902010843 .
- Roh MH, Fan S, Liu CJ, Margolis B . The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells . Journal of Cell Science . 116 . Pt 14 . 2895–906 . Jul 2003 . 12771187 . 10.1242/jcs.00500 . free .
- Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A . CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells . Molecular Biology of the Cell . 15 . 3 . 1324–33 . Mar 2004 . 14718572 . 363137 . 10.1091/mbc.E03-04-0235 .
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
- Fogg VC, Liu CJ, Margolis B . Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells . Journal of Cell Science . 118 . Pt 13 . 2859–69 . Jul 2005 . 15976445 . 10.1242/jcs.02412 . free .
- Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B . A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions . The Journal of Cell Biology . 178 . 3 . 387–98 . Jul 2007 . 17646395 . 2064851 . 10.1083/jcb.200609096 .
Notes and References
- Web site: Entrez Gene: CRB3 crumbs homolog 3 (Drosophila).
- Web site: Entrez Gene: CRB3 crumbs homolog 3 (Drosophila).