CRADD explained

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

Interactions

CRADD has been shown to interact with RIPK1 and Caspase 2.^{[1] [4] [5]}

Further reading

• Lennon G, Auffray C, Polymeropoulos M, Soares MB . The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression . Genomics . 33 . 1 . 151–2 . 1996 . 8617505 . 10.1006/geno.1996.0177 . free .
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
• Chou JJ, Matsuo H, Duan H, Wagner G . Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment . Cell . 94 . 2 . 171–80 . 1998 . 9695946 . 10.1016/S0092-8674(00)81417-8 . 16499945 . free .
• Horvat S, Medrano JF . A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region . Genomics . 54 . 1 . 159–64 . 1998 . 9806843 . 10.1006/geno.1998.5540 .
• Shearwin-Whyatt LM, Harvey NL, Kumar S . Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD . Cell Death Differ. . 7 . 2 . 155–65 . 2000 . 10713730 . 10.1038/sj.cdd.4400632 . free .
• Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L . Activation of the NF-kappaB pathway by caspase 8 and its homologs . Oncogene . 19 . 39 . 4451–60 . 2000 . 11002417 . 10.1038/sj.onc.1203812 . free .
• Droin N, Beauchemin M, Solary E, Bertrand R . Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade . Cancer Res. . 60 . 24 . 7039–47 . 2000 . 11156409 .
• Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES . Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria . J. Biol. Chem. . 277 . 16 . 13430–7 . 2002 . 11832478 . 10.1074/jbc.M108029200 . free .
• Tinel A, Tschopp J . The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress . Science . 304 . 5672 . 843–6 . 2004 . 15073321 . 10.1126/science.1095432 . 2004Sci...304..843T . 6583298 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Park HH, Wu H . Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly . J. Mol. Biol. . 357 . 2 . 358–64 . 2006 . 16434054 . 2902980 . 10.1016/j.jmb.2005.12.082 .
• Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B . Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage . Oncogene . 25 . 41 . 5683–92 . 2006 . 16652156 . 10.1038/sj.onc.1209569 . free .
• Park HH, Wu H . Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD . Acta Crystallographica Section F . 63 . Pt 3 . 229–32 . 2007 . 17329820 . 2330181 . 10.1107/S1744309107007889 .

Notes and References

1. Duan H, Dixit VM . RAIDD is a new 'death' adaptor molecule . Nature . 385 . 6611 . 86–9 . January 1997 . 8985253 . 10.1038/385086a0 . 1997Natur.385...86D . 2027.42/62739 . 4317538 . free .
2. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES . CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP . Cancer Res. . 57 . 4 . 615–9 . March 1997 . 9044836 .
3. Web site: Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain.
4. Tinel A, Tschopp J . The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress . Science . 304 . 5672 . 843–6 . May 2004 . 15073321 . 10.1126/science.1095432 . 2004Sci...304..843T . 6583298 .
5. Droin N, Beauchemin M, Solary E, Bertrand R . Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade . Cancer Res. . 60 . 24 . 7039–47 . December 2000 . 11156409 .