CPZ (gene) explained

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.^{[1] [2]}

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

Further reading

• Reznik SE, Fricker LD . Carboxypeptidases from A to z: implications in embryonic development and Wnt binding. . Cell. Mol. Life Sci. . 58 . 12–13 . 1790–804 . 2002 . 11766880 . 10.1007/PL00000819 . 22530649 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Fan X, Olson SJ, Blevins LS . Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. . J. Histochem. Cytochem. . 50 . 11 . 1509–16 . 2003 . 12417617 . 10.1177/002215540205001111. etal. free .
• Novikova EG, Reznik SE, Varlamov O, Fricker LD . Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. . J. Biol. Chem. . 275 . 7 . 4865–70 . 2000 . 10671522 . 10.1074/jbc.275.7.4865 . free .
• Novikova EG, Fricker LD . Purification and characterization of human metallocarboxypeptidase Z. . Biochem. Biophys. Res. Commun. . 256 . 3 . 564–8 . 1999 . 10080937 . 10.1006/bbrc.1999.0378 .

Notes and References

1. Song L, Fricker LD . Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase . J Biol Chem . 272 . 16 . 10543–50 . May 1997 . 9099699 . 10.1074/jbc.272.16.10543 . free .
2. Web site: Entrez Gene: CPZ carboxypeptidase Z.