CPSF3 explained

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.^{[1] [2]}

Further reading

• Murthy KG, Manley JL . The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. . Genes Dev. . 9 . 21 . 2672–83 . 1995 . 7590244 . 10.1101/gad.9.21.2672 . free .
• Jenny A, Hauri HP, Keller W . Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. . Mol. Cell. Biol. . 14 . 12 . 8183–90 . 1994 . 7969155 . 10.1128/MCB.14.12.8183. 359357 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Thuresson AC, Aström J, Aström A . Multiple forms of poly(A) polymerases in human cells. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 3 . 979–83 . 1994 . 8302877 . 10.1073/pnas.91.3.979 . 521437 . 1994PNAS...91..979T . etal. free .
• McCracken S, Fong N, Yankulov K . The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. . Nature . 385 . 6614 . 357–61 . 1997 . 9002523 . 10.1038/385357a0 . 1997Natur.385..357M . 4307073 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Takagaki Y, Manley JL . Complex protein interactions within the human polyadenylation machinery identify a novel component. . Mol. Cell. Biol. . 20 . 5 . 1515–25 . 2000 . 10669729 . 10.1128/MCB.20.5.1515-1525.2000 . 85326 .
• de Vries H, Rüegsegger U, Hübner W . Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. . EMBO J. . 19 . 21 . 5895–904 . 2000 . 11060040 . 10.1093/emboj/19.21.5895 . 305781 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kaufmann I, Martin G, Friedlein A . Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. . EMBO J. . 23 . 3 . 616–26 . 2005 . 14749727 . 10.1038/sj.emboj.7600070 . 1271804 . etal.
• Calzado MA, Sancho R, Muñoz E . Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression. . J. Virol. . 78 . 13 . 6846–54 . 2004 . 15194760 . 10.1128/JVI.78.13.6846-6854.2004 . 421638 .
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . etal. free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Mandel CR, Kaneko S, Zhang H . Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. . Nature . 444 . 7121 . 953–6 . 2007 . 17128255 . 10.1038/nature05363 . etal. 3866582 .
• de la Vega L, Sánchez-Duffhues G, Fresno M . The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. . J. Mol. Biol. . 372 . 2 . 317–30 . 2007 . 17669424 . 10.1016/j.jmb.2007.06.075 . etal.

Notes and References

1. Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W . Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I . Science . 274 . 5292 . 1514–7 . Dec 1996 . 8929409 . 10.1126/science.274.5292.1514 . 1996Sci...274.1514J . 12958377 .
2. Web site: Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa.