CPNE8 explained

Copine-8 is a protein that in humans is encoded by the CPNE8 gene.^{[1] [2]}

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.

Further reading

• Creutz CE . The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans . J. Biol. Chem. . 273 . 3 . 1393–1402 . 1998 . 9430674 . 10.1074/jbc.273.3.1393 . vanc. Tomsig JL . Snyder SL . 3 . Gautier . MC . Skouri . F . Beisson . J . Cohen . J . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–1795 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Tomsig JL, Creutz CE . Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein . Biochemistry . 39 . 51 . 16163–16175 . 2001 . 11123945 . 10.1021/bi0019949 .
• Wiemann S . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–435 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ramsey H . Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation . Leukemia . 17 . 8 . 1665–1666 . 2003 . 12886257 . 10.1038/sj.leu.2403048 . vanc. Zhang DE . Richkind K . 3 . Burcoglu-o'Ral . A . Hromas . R . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wiemann S . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–2144 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–D418 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .

Notes and References

1. Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B . Cloning, molecular characterization, and expression analysis of Copine 8 . Biochem Biophys Res Commun . 303 . 3 . 842–847 . Apr 2003 . 12670487 . 10.1016/S0006-291X(03)00445-5 .
2. Web site: Entrez Gene: CPNE8 copine VIII.