CPNE6 explained

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.^{[1] [2]}

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Nakayama T, Yaoi T, Kuwajima G . Localization and subcellular distribution of N-copine in mouse brain . J. Neurochem. . 72 . 1 . 373–9 . 1999 . 9886090 . 10.1046/j.1471-4159.1999.0720373.x . free .
• Nakayama T, Yaoi T, Kuwajima G . Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma . FEBS Lett. . 453 . 1–2 . 77–80 . 1999 . 10403379 . 10.1016/S0014-5793(99)00700-0 . etal. free .
• Caudell EG, Caudell JJ, Tang CH . Characterization of human copine III as a phosphoprotein with associated kinase activity . Biochemistry . 39 . 42 . 13034–43 . 2000 . 11041869 . 10.1021/bi001250v . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Nakayama T, Yaoi T, Yasui M, Kuwajima G . N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression . FEBS Lett . 428 . 1–2 . 80–4 . Jul 1998 . 9645480 . 10.1016/S0014-5793(98)00497-9 . 27969998 .
2. Web site: Entrez Gene: CPNE6 copine VI (neuronal).