CPLX2 explained

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.^{[1] [2] [3]}

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Abe T . [The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis] . Tanpakushitsu Kakusan Koso . 47 . 7 . 794–800 . 2002 . 12058476 .
• Christensen VL, Johnston NP . Effect of time of day of insemination and the position of the egg in the oviduct on the fertility of turkeys . Poult. Sci. . 56 . 2 . 458–62 . 1978 . 605033 . 10.3382/ps.0560458. free .
• Morgans CW . A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina . J. Neurosci. . 16 . 21 . 6713–21 . 1996 . 8824312 . 10.1523/JNEUROSCI.16-21-06713.1996. vanc. Brandstätter JH . Kellerman J . 3 . Betz . H . Wässle . H . 6579260 . free.
• Harrison PJ, Eastwood SL . Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia . Lancet . 352 . 9141 . 1669–73 . 1998 . 9853440 . 10.1016/S0140-6736(98)03341-8 . 45239545 .
• Ishizuka T . Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex . Neuroscience . 88 . 1 . 295–306 . 1999 . 10051208 . 10.1016/S0306-4522(98)00223-1 . vanc. Saisu H . Odani S . 3 . Kumanishi . T . Abe . T . 46636775 .
• Yamada M . Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types . Neuroscience . 93 . 1 . 7–18 . 1999 . 10430466 . 10.1016/S0306-4522(99)00104-9 . vanc. Saisu H . Ishizuka T . 3 . Takahashi . H . Abe . T . 21532356 .
• Pabst S . Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions . J. Biol. Chem. . 275 . 26 . 19808–18 . 2000 . 10777504 . 10.1074/jbc.M002571200 . vanc. Hazzard JW . Antonin W . 3 . Südhof . TC . Jahn . R . Rizo . J . Fasshauer . D . free .
• Eastwood SL, Cotter D, Harrison PJ . Cerebellar synaptic protein expression in schizophrenia . Neuroscience . 105 . 1 . 219–29 . 2001 . 11483314 . 10.1016/S0306-4522(01)00141-5 . 34257327 .
• Eastwood SL, Harrison PJ . Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins . Brain Res. Bull. . 55 . 5 . 569–78 . 2001 . 11576753 . 10.1016/S0361-9230(01)00530-5 . 23012653 .
• Pabst S . Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis . J. Biol. Chem. . 277 . 10 . 7838–48 . 2002 . 11751907 . 10.1074/jbc.M109507200 . vanc. Margittai M . Vainius D . 3 . Langen . R . Jahn . R . Fasshauer . D . free. 11858/00-001M-0000-0012-F415-9. free.
• Sawada K . Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness . Mol. Psychiatry . 7 . 5 . 484–92 . 2002 . 12082566 . 10.1038/sj.mp.4000978 . vanc. Young CE . Barr AM . 3 . Longworth . K . Takahashi . S . Arango . V . Mann . J J . Dwork . A J . Falkai . P . free .
• Hu K, Carroll J, Rickman C, Davletov B . Action of complexin on SNARE complex . J. Biol. Chem. . 277 . 44 . 41652–6 . 2003 . 12200427 . 10.1074/jbc.M205044200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Edwardson JM . Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II . J. Biol. Chem. . 278 . 33 . 30849–53 . 2003 . 12807877 . 10.1074/jbc.M304615200 . vanc. Wang CT . Gong B . 3 . Wyttenbach . A . Bai . J . Jackson . MB . Chapman . ER . Morton . AJ . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Eastwood SL, Harrison PJ . Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons . . 73 . 2–3 . 159–72 . 2005 . 15653259 . 10.1016/j.schres.2004.05.010 . 2335413 .
• DiProspero NA . Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements . J. Neurocytol. . 33 . 5 . 517–33 . 2005 . 15906159 . 10.1007/s11068-004-0514-8 . vanc. Chen EY . Charles V . 3 . Plomann . Markus . Kordower . Jeffrey H. . Tagle . Danilo A. . 20082165 .

Notes and References

1. McMahon HT, Missler M, Li C, Sudhof TC . Complexins: cytosolic proteins that regulate SNAP receptor function . Cell . 83 . 1 . 111–9 . Nov 1995 . 7553862 . 10.1016/0092-8674(95)90239-2 . 675343 . free .
2. Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA . Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity . Gene . 359 . 127–37 . Sep 2005 . 16162394 . 10.1016/j.gene.2005.07.005 .
3. Web site: Entrez Gene: CPLX2 complexin 2.