CPLX1 explained

Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.^{[1] [2]}

Function

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.^[3]

Interactions

CPLX1 has been shown to interact with SNAP-25^{[4] [5]} and STX1A.^{[6] [4] [5]}

Further reading

• Abe T . [The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis] . Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme . 47 . 7 . 794–800 . Jun 2002 . 12058476 .
• Ishizuka T, Saisu H, Odani S, Abe T . Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals . Biochemical and Biophysical Research Communications . 213 . 3 . 1107–14 . Aug 1995 . 7654227 . 10.1006/bbrc.1995.2241 .
• Harrison PJ, Eastwood SL . Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia . Lancet . 352 . 9141 . 1669–73 . Nov 1998 . 9853440 . 10.1016/S0140-6736(98)03341-8 . 45239545 .
• Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T . Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex . Neuroscience . 88 . 1 . 295–306 . Jan 1999 . 10051208 . 10.1016/S0306-4522(98)00223-1 . 46636775 .
• Eastwood SL, Cotter D, Harrison PJ . Cerebellar synaptic protein expression in schizophrenia . Neuroscience . 105 . 1 . 219–29 . 2001 . 11483314 . 10.1016/S0306-4522(01)00141-5 . 34257327 .
• Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J . Three-dimensional structure of the complexin/SNARE complex . Neuron . 33 . 3 . 397–409 . Jan 2002 . 11832227 . 10.1016/S0896-6273(02)00583-4 . 17878965 . free .
• Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arango V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG . Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness . Molecular Psychiatry . 7 . 5 . 484–92 . 2002 . 12082566 . 10.1038/sj.mp.4000978 . free .
• Basso M, Giraudo S, Corpillo D, Bergamasco B, Lopiano L, Fasano M . Proteome analysis of human substantia nigra in Parkinson's disease . Proteomics . 4 . 12 . 3943–52 . Dec 2004 . 15526345 . 10.1002/pmic.200400848 . 11383/1491905 . 23119746 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Giraudo CG, Eng WS, Melia TJ, Rothman JE . A clamping mechanism involved in SNARE-dependent exocytosis . Science . 313 . 5787 . 676–80 . Aug 2006 . 16794037 . 10.1126/science.1129450 . 2006Sci...313..676G . 28309295 . free .

Notes and References

1. McMahon HT, Missler M, Li C, Südhof TC . Complexins: cytosolic proteins that regulate SNAP receptor function . Cell . 83 . 1 . 111–9 . Oct 1995 . 7553862 . 10.1016/0092-8674(95)90239-2 . 675343 . free .
2. Web site: Entrez Gene: CPLX1 complexin 1.
3. Web site: Entrez Gene: CPLX1 complexin 1.
4. Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J . Three-dimensional structure of the complexin/SNARE complex . Neuron . 33 . 3 . 397–409 . Jan 2002 . 11832227 . 10.1016/S0896-6273(02)00583-4 . 17878965 . free .
5. Hu K, Carroll J, Rickman C, Davletov B . Action of complexin on SNARE complex . The Journal of Biological Chemistry . 277 . 44 . 41652–6 . Nov 2002 . 12200427 . 10.1074/jbc.M205044200 . free .
6. Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J . A conformational switch in syntaxin during exocytosis: role of munc18 . The EMBO Journal . 18 . 16 . 4372–82 . Aug 1999 . 10449403 . 1171512 . 10.1093/emboj/18.16.4372 .