CPEB1 explained

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.^{[1] [2]}

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.^[2]

Further reading

• Mendez R, Richter JD . Translational control by CPEB: a means to the end . Nat. Rev. Mol. Cell Biol. . 2 . 7 . 521–9 . 2001 . 11433366 . 10.1038/35080081 . 815958 . free .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Huang YS, Carson JH, Barbarese E, Richter JD . Facilitation of dendritic mRNA transport by CPEB . Genes Dev. . 17 . 5 . 638–53 . 2003 . 12629046 . 10.1101/gad.1053003 . 196011 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wilczynska A, Aigueperse C, Kress M . The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules . J. Cell Sci. . 118 . Pt 5 . 981–92 . 2005 . 15731006 . 10.1242/jcs.01692 . etal. free .
• Sasayama T, Marumoto T, Kunitoku N . Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1 . Genes Cells . 10 . 7 . 627–38 . 2005 . 15966895 . 10.1111/j.1365-2443.2005.00870.x . 24879593 . etal. free . 20.500.14094/D2002840 . free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.

Notes and References

1. Welk JF, Charlesworth A, Smith GD, MacNicol AM . Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein . Gene . 263 . 1–2 . 113–20 . Mar 2001 . 11223249 . 10.1016/S0378-1119(00)00588-6 .
2. Web site: Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1.