CPA5 explained

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.^{[1] [2]}

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]

Further reading

• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Bentley L, Nakabayashi K, Monk D . The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome . J. Med. Genet. . 40 . 4 . 249–56 . 2003 . 12676894 . 10.1136/jmg.40.4.249 . 1735416 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Bonora E, Bacchelli E, Levy ER . Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region . Mol. Psychiatry . 7 . 3 . 289–301 . 2002 . 11920156 . 10.1038/sj.mp.4001004 . etal. 13282515 .
• A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium . Hum. Mol. Genet. . 7 . 3 . 571–8 . 1998 . 9546821 . 10.1093/hmg/7.3.571 . free . 11858/00-001M-0000-0012-C9D8-C . free .

Notes and References

1. Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD . Identification and characterization of three members of the human metallocarboxypeptidase gene family . J Biol Chem . 277 . 17 . 14954–64 . Apr 2002 . 11836249 . 10.1074/jbc.M112254200 . free .
2. Web site: Entrez Gene: CPA5 carboxypeptidase A5.