CPA4 (gene) explained

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.^{[1] [2] [3]}

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kayashima T . The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain . Hum. Genet. . 112 . 3 . 220–6 . 2003 . 12552318 . 10.1007/s00439-002-0891-3 . vanc. Yamasaki K . Yamada T . 3 . Sakai . H . Miwa . N . Ohta . T . Yoshiura . K . Matsumoto . N . Nakane . Y . 45644546 .
• Bentley L . The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome . J. Med. Genet. . 40 . 4 . 249–56 . 2003 . 12676894 . 10.1136/jmg.40.4.249 . 1735416 . vanc. Nakabayashi K . Monk D . 3 . Beechey . C . Peters . J . Birjandi . Z . Khayat . FE . Patel . M . Preece . MA .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• García-Castellanos R . Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin . Cell. Mol. Life Sci. . 62 . 17 . 1996–2014 . 2005 . 16091843 . 10.1007/s00018-005-5174-4 . vanc. Bonet-Figueredo R . Pallarés I . 3 . Ventura . S. . Avilés . F. X. . Vendrell . J. . Gomis-Rütha . F. X. . 21858832 . 11139196.

Notes and References

1. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI . Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells . Cancer Res . 59 . 12 . 2981–8 . Jul 1999 . 10383164 .
2. Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T . Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32 . Genomics . 66 . 2 . 221–5 . Aug 2000 . 10860668 . 10.1006/geno.2000.6206 .
3. Web site: Entrez Gene: CPA4 carboxypeptidase A4.