CP-93129 explained

CP-93129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.[2] [3] [4] [5]

Notes and References

  1. Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK . 6 . 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole . Journal of Medicinal Chemistry . 33 . 8 . 2087–93 . August 1990 . 2374139 . 10.1021/jm00170a007 .
  2. De Groote L, Olivier B, Westenberg HG . Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice . European Journal of Pharmacology . 476 . 1–2 . 71–7 . August 2003 . 12969751 . 10.1016/s0014-2999(03)02154-x .
  3. Przegaliński E, Papla I, Siwanowicz J, Filip M . Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats . European Neuropsychopharmacology . 14 . 3 . 217–25 . May 2004 . 15056481 . 10.1016/S0924-977X(03)00106-8 . 308992 .
  4. Bramley JR, Sollars PJ, Pickard GE, Dudek FE . 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus . Journal of Neurophysiology . 93 . 6 . 3157–64 . June 2005 . 15716370 . 10.1152/jn.00770.2004 . 10.1.1.325.6052 .
  5. Saitow F, Murano M, Suzuki H . Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei . Journal of Neurophysiology . 101 . 3 . 1361–74 . March 2009 . 19144744 . 10.1152/jn.90750.2008 .

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