CP-809101 explained

CP-809101 is a drug which acts as a potent and selective 5-HT2C receptor agonist.[1] It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.[2] [3]

Notes and References

  1. Strong PV, Greenwood BN, Fleshner M . The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats . Psychopharmacology . 203 . 4 . 665–75 . May 2009 . 19037632 . 10.1007/s00213-008-1413-3 . 24956531 .
  2. Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA . CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity . Neuropharmacology . 52 . 2 . 279–90 . February 2007 . 16949622 . 10.1016/j.neuropharm.2006.07.024 . 46489320 .
  3. Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K . Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation . Drug Metabolism and Disposition . 35 . 6 . 848–58 . June 2007 . 17344339 . 10.1124/dmd.106.013649 . 29863246 . https://web.archive.org/web/20190225184746/http://pdfs.semanticscholar.org/72b2/41dd694746eaa4424134533804fd4a53bfd2.pdf . dead . 2019-02-25 .

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