CP-154,526 explained
CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.[1]
CP-154,526 is under investigation for the potential treatment of alcoholism.[2] [3]
See also
Further reading
- Seymour PA, Schmidt AW, Schulz DW . The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review . CNS Drug Reviews . 9 . 1 . 57–96 . 2006 . 12595912 . 10.1111/j.1527-3458.2003.tb00244.x . 6741649 .
- Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV . Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal . Molecular Pharmacology . 77 . 5 . 864–73 . May 2010 . 20159948 . 10.1124/mol.109.062463 . 18588298 .
- Kobayashi T, Kiyokawa Y, Takeuchi Y, Mori Y . Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats . Chemical Senses . 36 . 7 . 623–32 . September 2011 . 21502338 . 10.1093/chemse/bjr017 . free .
Notes and References
- Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD, Winston EN, Chen YL, Heym J . CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors . Proceedings of the National Academy of Sciences of the United States of America . 93 . 19 . 10477–82 . September 1996 . 8816826 . 38410 . 10.1073/pnas.93.19.10477 . 1996PNAS...9310477S . free .
- Web site: Drug Has Potential To Prevent Alcoholics From Relapsing . 2008-08-02 . Science News . ScienceDaily . 2008-08-09.
- Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ . Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism . Proceedings of the National Academy of Sciences of the United States of America . 105 . 26 . 9070–5 . July 2008 . 18591672 . 2449366 . 10.1073/pnas.0710181105 . 2008PNAS..105.9070P . free .