CP-132,484 explained

CP-132,484 is a tryptamine derivative which acts as a potent and selective agonist for the 5-HT₂ family of serotonin receptors.^[1] It has reasonable selectivity for 5-HT_2A and 5-HT_2C subtypes over 5-HT_2B, but is only slightly selective for 5-HT_2A over 5-HT_2C. This compound and several related analogues have been shown to have ocular hypotensive activity in animal models, suggesting they may be useful for the treatment of glaucoma.^[2]

See also

• AL-37350A
• AL-38022A
• 1-Methylpsilocin
• 4,5-DHP-DMT

Notes and References

1. Macor JE, Fox CB, Johnson C, Koe BK, Lebel LA, Zorn SH . Koe BK . Oct 1992 . 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors . Journal of Medicinal Chemistry . 35 . 20. 3625–32 . 10.1021/jm00098a005 . 1433172 .
2. May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA . A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole . Journal of Medicinal Chemistry . 46 . 19 . 4188–95 . September 2003 . 12954071 . 10.1021/jm030205t . 10.1.1.688.6169 .