COX7C explained

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.^{[1] [2]}

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[2]

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG . Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. . Prog. Nucleic Acid Res. Mol. Biol. . Progress in Nucleic Acid Research and Molecular Biology . 61 . 309–44 . 1998 . 9752724 . 10.1016/S0079-6603(08)60830-2 . 9780125400619 . free .
• Sirchia R, Luparello C . Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. . Biol. Chem. . 388 . 5 . 457–65 . 2007 . 17516841 . 10.1515/BC.2007.059 . 2286919 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kaminishi H, Hamatake H, Cho T . Activation of blood clotting factors by microbial proteinases. . FEMS Microbiol. Lett. . 121 . 3 . 327–32 . 1994 . 7926688 . 10.1111/j.1574-6968.1994.tb07121.x . etal. free .
• Koga Y, Fabrizi GM, Mita S . Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. . Nucleic Acids Res. . 18 . 3 . 684 . 1990 . 2155413 . 10.1093/nar/18.3.684 . 333506 . etal.
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO . Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. . Eur. J. Biochem. . 203 . 1–2 . 193–9 . 1992 . 1309697 . 10.1111/j.1432-1033.1992.tb19847.x .

Notes and References

1. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T . Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping . Cytogenet Cell Genet . 83 . 3–4 . 226–7 . Mar 1999 . 10072584 . 10.1159/000015185 .
2. Web site: Entrez Gene: COX7C cytochrome c oxidase subunit VIIc.