COX7A1 explained

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.^{[1] [2] [3]}

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG . Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex . Prog. Nucleic Acid Res. Mol. Biol. . 61 . 309–344 . 1998 . 9752724 . 10.1016/S0079-6603(08)60830-2 . Progress in Nucleic Acid Research and Molecular Biology . 978-0-12-540061-9 . free .
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO . Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart . Eur. J. Biochem. . 203 . 1–2 . 193–199 . 1992 . 1309697 . 10.1111/j.1432-1033.1992.tb19847.x .
• Wolz W, Kress W, Mueller CR . Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M . Genomics . 45 . 2 . 438–442 . 1998 . 9344674 . 10.1006/geno.1997.4937 .
• Schmidt TR, Goodman M, Grossman LI . Molecular evolution of the COX7A gene family in primates . Mol. Biol. Evol. . 16 . 5 . 619–26 . 1999 . 10335655 . 10.1093/oxfordjournals.molbev.a026144. free .
• Yu M, Jaradat SA, Grossman LI . Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH) . Biochim. Biophys. Acta . 1574 . 3 . 345–53 . 2002 . 11997101 . 10.1016/s0167-4781(02)00228-2.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Grimwood J . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–535 . 2004 . 15057824 . 10.1038/nature02399 . vanc. Gordon LA . Olsen A . 3 . Terry . Astrid . Schmutz . Jeremy . Lamerdin . Jane . Hellsten . Uffe . Goodstein . David . Couronne . Olivier . 2004Natur.428..529G . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA . Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase . Gene . 119 . 2 . 299–305 . Nov 1992 . 1327965 . 10.1016/0378-1119(92)90287-Y .
2. Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA . Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase . Nucleic Acids Res . 17 . 17 . 7107 . Oct 1989 . 2550906 . 318441 . 10.1093/nar/17.17.7107 .
3. Web site: Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle).