COX6C explained
Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[1] [2]
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.
Further reading
- Lenka N, Vijayasarathy C, Mullick J, Avadhani NG . Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. . Prog. Nucleic Acid Res. Mol. Biol. . Progress in Nucleic Acid Research and Molecular Biology . 61 . 309–44 . 1998 . 9752724 . 10.1016/S0079-6603(08)60830-2 . 9780125400619 . free .
- Sirchia R, Luparello C . Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. . Biol. Chem. . 388 . 5 . 457–65 . 2007 . 17516841 . 10.1515/BC.2007.059 . 2286919 .
- Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
- Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Kish SJ, Mastrogiacomo F, Guttman M . Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change? . J. Neurochem. . 72 . 2 . 700–7 . 1999 . 9930743 . 10.1046/j.1471-4159.1999.0720700.x . 32587972 . etal. free .
- Wang FL, Wang Y, Wong WK . Two differentially expressed genes in normal human prostate tissue and in carcinoma. . Cancer Res. . 56 . 16 . 3634–7 . 1996 . 8705997 . etal.
- Otsuka M, Mizuno Y, Yoshida M . Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. . Nucleic Acids Res. . 16 . 22 . 10916 . 1989 . 2849755 . 10.1093/nar/16.22.10916 . 338951 . etal.
Notes and References
- Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T . Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping . Cytogenet Cell Genet . 83 . 3–4 . 226–7 . Mar 1999 . 10072584 . 10.1159/000015185 .
- Web site: Entrez Gene: COX6C cytochrome c oxidase subunit VIc.