CORO2A explained
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[1]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[2]
Further reading
- Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J . Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 . The EMBO Journal . 22 . 6 . 1336–46 . March 2003 . 12628926 . 151047 . 10.1093/emboj/cdg120 .
- Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J . N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso . Molecular Cell . 12 . 3 . 723–34 . September 2003 . 14527417 . 10.1016/j.molcel.2003.08.008 . free .
- Marshall TW, Aloor HL, Bear JE . Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway . Journal of Cell Science . 122 . Pt 17 . 3061–9 . September 2009 . 19654210 . 2729258 . 10.1242/jcs.051482 .
- Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA . Common variants in FOXP1 are associated with generalized vitiligo . Nature Genetics . 42 . 7 . 576–8 . July 2010 . 20526340 . 2893242 . 10.1038/ng.602 .
- Zaphiropoulos PG, Toftgård R . cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region . DNA and Cell Biology . 15 . 12 . 1049–56 . December 1996 . 8985118 . 10.1089/dna.1996.15.1049 .
Notes and References
- Web site: Entrez Gene: Coronin, actin binding protein, 2A. 2012-01-03 .
- Web site: Entrez Gene: Coronin, actin binding protein, 2A. 2012-01-03 .
