COPS8 explained

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.^{[1] [2] [3]}

The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

• Schwechheimer C, Deng XW . COP9 signalosome revisited: a novel mediator of protein degradation . Trends Cell Biol. . 11 . 10 . 420–6 . 2001 . 11567875 . 10.1016/S0962-8924(01)02091-8 .
• Wolf DA, Zhou C, Wee S . The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? . Nat. Cell Biol. . 5 . 12 . 1029–33 . 2004 . 14647295 . 10.1038/ncb1203-1029 . 37458780 .
• Chamovitz DA . The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch . Cell . 86 . 1 . 115–21 . 1996 . 8689678 . 10.1016/S0092-8674(00)80082-3 . Wei N . Osterlund MT . Von Arnim . Albrecht G . Staub . Jeffrey M . Matsui . Minami . Deng . Xing-Wang . free .
• Hillier LD . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . Lennon G . Becker M . Bonaldo . M F . Chiapelli . B . Chissoe . S . Dietrich . N . Dubuque . T . Favello . A . free .
• Seeger M . A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits . FASEB J. . 12 . 6 . 469–78 . 1998 . 9535219 . 10.1096/fasebj.12.6.469. Kraft R . Ferrell K . Bech-Otschir . D . Dumdey . R . Schade . R . Gordon . C . Naumann . M . Dubiel . W . free . 25424324 .
• Wei N . The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex . Curr. Biol. . 8 . 16 . 919–22 . 1998 . 9707402 . 10.1016/S0960-9822(07)00372-7 . Tsuge T . Serino G . Dohmae . Naoshi . Takio . Koji . Matsui . Minami . Deng . Xing-Wang . 13873982 . free . 1998CBio....8..919W .
• Naumann M . COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK . J. Biol. Chem. . 274 . 50 . 35297–300 . 2000 . 10585392 . 10.1074/jbc.274.50.35297 . Bech-Otschir D . Huang X . Ferrell . K . Dubiel . W . free.
• Cohen H . Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome . J. Biol. Chem. . 275 . 50 . 39081–9 . 2001 . 10991940 . 10.1074/jbc.M004900200 . Azriel A . Cohen T . Meraro . D . Hashmueli . S . Bech-Otschir . D . Kraft . R . Dubiel . W . Levi . BZ . free .
• Gizatullin RZ . Human COP9 subunit 8 homolog gene SGN8 Map position 2q37 . Chromosome Res. . 8 . 6 . 559 . 2001 . 11032325 . 10.1023/A:1009279908306 . Muravenko OV . Al-Amin AN . Wang . F. . Protopopov . A. I. . Kashuba . V. I. . Zelenin . A. V. . Zabarovsky . E. R. . 12957157 .
• Bech-Otschir D . COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system . EMBO J. . 20 . 7 . 1630–9 . 2001 . 11285227 . 10.1093/emboj/20.7.1630 . 145508 . Kraft R . Huang X . Henklein . P . Kapelari . B . Pollmann . C . Dubiel . W .
• Lyapina S . Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome . Science . 292 . 5520 . 1382–5 . 2001 . 11337588 . 10.1126/science.1059780 . Cope G . Shevchenko A . Serino . G . Tsuge . T . Zhou . C . Wolf . DA . Wei . N . Shevchenko . A . 2001Sci...292.1382L . 14224920 .
• Hoareau Alves K, Bochard V, Réty S, Jalinot P . Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome . FEBS Lett. . 527 . 1–3 . 15–21 . 2002 . 12220626 . 10.1016/S0014-5793(02)03147-2 . 39308598 . free .
• Sun Y, Wilson MP, Majerus PW . Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1 . J. Biol. Chem. . 277 . 48 . 45759–64 . 2003 . 12324474 . 10.1074/jbc.M208709200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Serino G . Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex . Plant Cell . 15 . 3 . 719–31 . 2003 . 12615944 . 10.1105/tpc.009092 . 150025 . Su H . Peng Z . Tsuge . T . Wei . N . Gu . H . Deng . XW .
• Uhle S . Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome . EMBO J. . 22 . 6 . 1302–12 . 2003 . 12628923 . 10.1093/emboj/cdg127 . 151059 . Medalia O . Waldron R . Dumdey . R . Henklein . P . Bech-Otschir . D . Huang . X . Berse . M . Sperling . J .

Notes and References

1. Chamovitz DA, Deng XW . The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms . Cell . 82 . 3 . 353–4 . Sep 1995 . 7634324 . 10.1016/0092-8674(95)90423-9 . free .
2. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y . The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage . Cell . 113 . 3 . 357–67 . May 2003 . 12732143 . 10.1016/S0092-8674(03)00316-7 . 11639677 . free .
3. Web site: Entrez Gene: COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis).