COPS7A explained

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.^[1]

Further reading

• Wolf DA, Zhou C, Wee S . The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? . Nat. Cell Biol. . 5 . 12 . 1029–33 . 2004 . 14647295 . 10.1038/ncb1203-1029 . 37458780 .
• Seeger M . A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits . FASEB J. . 12 . 6 . 469–78 . 1998 . 9535219 . 10.1096/fasebj.12.6.469. Kraft R . Ferrell K . Bech-Otschir . D . Dumdey . R . Schade . R . Gordon . C . Naumann . M . Dubiel . W . free . 25424324 .
• Wei N . The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex . Curr. Biol. . 8 . 16 . 919–22 . 1998 . 9707402 . 10.1016/S0960-9822(07)00372-7 . Tsuge T . Serino G . Dohmae . Naoshi . Takio . Koji . Matsui . Minami . Deng . Xing-Wang . 13873982 . free . 1998CBio....8..919W .
• Bech-Otschir D . COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system . EMBO J. . 20 . 7 . 1630–9 . 2001 . 11285227 . 10.1093/emboj/20.7.1630 . 145508 . Kraft R . Huang X . Henklein . P . Kapelari . B . Pollmann . C . Dubiel . W .
• Lyapina S . Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome . Science . 292 . 5520 . 1382–5 . 2001 . 11337588 . 10.1126/science.1059780 . Cope G . Shevchenko A . Serino . G . Tsuge . T . Zhou . C . Wolf . DA . Wei . N . Shevchenko . A . 2001Sci...292.1382L . 14224920 .
• Wang Y, Devereux W, Stewart TM, Casero RA . Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression . Biochem. J. . 366 . Pt 1 . 79–86 . 2002 . 12020345 . 10.1042/BJ20020211 . 1222765 .
• Hoareau Alves K, Bochard V, Réty S, Jalinot P . Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome . FEBS Lett. . 527 . 1–3 . 15–21 . 2002 . 12220626 . 10.1016/S0014-5793(02)03147-2 . 39308598 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Serino G . Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex . Plant Cell . 15 . 3 . 719–31 . 2003 . 12615944 . 10.1105/tpc.009092 . 150025 . Su H . Peng Z . Tsuge . T . Wei . N . Gu . H . Deng . XW .
• Uhle S . Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome . EMBO J. . 22 . 6 . 1302–12 . 2003 . 12628923 . 10.1093/emboj/cdg127 . 151059 . Medalia O . Waldron R . Dumdey . R . Henklein . P . Bech-Otschir . D . Huang . X . Berse . M . Sperling . J .
• Groisman R . The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage . Cell . 113 . 3 . 357–67 . 2003 . 12732143 . 10.1016/S0092-8674(03)00316-7 . Polanowska J . Kuraoka I . Sawada . Jun-Ichi . Saijo . Masafumi . Drapkin . Ronny . Kisselev . Alexei F. . Tanaka . Kiyoji . Nakatani . Yoshihiro . 11639677 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Obuse C . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 . Nat. Cell Biol. . 6 . 11 . 1135–41 . 2004 . 15502821 . 10.1038/ncb1187 . Iwasaki O . Kiyomitsu T . Goshima . Gohta . Toyoda . Yusuke . Yanagida . Mitsuhiro . 39408000 .
• Stelzl U . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . Worm U . Lalowski M . Haenig . Christian . Brembeck . Felix H. . Goehler . Heike . Stroedicke . Martin . Zenkner . Martina . Schoenherr . Anke . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Web site: Entrez Gene: COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis).