COP9 constitutive photomorphogenic homolog subunit 5 explained

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.^[1]

Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,^{[2] [3]} GFER,^[4] BCL3,^[5] Ubiquitin carboxy-terminal hydrolase L1,^[6] S100A7^[7] and C-jun.^[8]

See also

• COPS1
• COPS2
• COPS3
• COPS4
• COPS6
• COPS7A
• COPS7B
• COPS8

Further reading

• Wolf DA, Zhou C, Wee S . The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? . Nature Cell Biology . 5 . 12 . 1029–33 . December 2003 . 14647295 . 10.1038/ncb1203-1029 . 37458780 .
• Claret FX, Hibi M, Dhut S, Toda T, Karin M . A new group of conserved coactivators that increase the specificity of AP-1 transcription factors . Nature . 383 . 6599 . 453–7 . October 1996 . 8837781 . 10.1038/383453a0 . 1996Natur.383..453C . 4353893 .
• Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW . Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly . The Journal of Biological Chemistry . 272 . 43 . 27042–52 . October 1997 . 9341143 . 10.1074/jbc.272.43.27042 . free .
• Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W . 6 . A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits . FASEB Journal . 12 . 6 . 469–78 . April 1998 . 9535219 . 10.1096/fasebj.12.6.469 . free . 25424324 .
• Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW . The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex . Current Biology . 8 . 16 . 919–22 . 1998 . 9707402 . 10.1016/S0960-9822(07)00372-7 . 13873982 . free . 1998CBio....8..919W .
• Tomoda K, Kubota Y, Kato J . Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 . Nature . 398 . 6723 . 160–5 . March 1999 . 10086358 . 10.1038/18230 . 204991745 .
• Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A . 6 . The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators . Oncogene . 18 . 22 . 3316–23 . June 1999 . 10362352 . 10.1038/sj.onc.1202717 . 2356435 .
• Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H . JAB1 interacts with both the progesterone receptor and SRC-1 . The Journal of Biological Chemistry . 275 . 12 . 8540–8 . March 2000 . 10722692 . 10.1074/jbc.275.12.8540 . free .
• Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R . 6 . Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity . Nature . 404 . 6778 . 617–21 . April 2000 . 10766246 . 10.1038/35007098 . 2000Natur.404..617B . 4384395 .
• Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J . 6 . Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 . Nature . 408 . 6809 . 211–6 . November 2000 . 11089976 . 10.1038/35041591 . 2000Natur.408..211K . 205010648 .
• Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W . COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system . The EMBO Journal . 20 . 7 . 1630–9 . April 2001 . 11285227 . 145508 . 10.1093/emboj/20.7.1630 .
• Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ . 6 . Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome . Science . 292 . 5520 . 1382–5 . May 2001 . 11337588 . 10.1126/science.1059780 . 2001Sci...292.1382L . 14224920 .
• Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY . 6 . The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex . The Journal of Biological Chemistry . 277 . 3 . 2302–10 . January 2002 . 11704659 . 10.1074/jbc.M104431200 . free .
• Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW . 6 . Jab1 interacts directly with HIF-1alpha and regulates its stability . The Journal of Biological Chemistry . 277 . 1 . 9–12 . January 2002 . 11707426 . 10.1074/jbc.C100442200 . free .
• Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F . 6 . Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway . FASEB Journal . 16 . 1 . 90–2 . January 2002 . 11709497 . 10.1096/fj.01-0506fje . free . 7006611 .
• Dai YS, Cserjesi P . The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer . The Journal of Biological Chemistry . 277 . 15 . 12604–12 . April 2002 . 11812799 . 10.1074/jbc.M200283200 . free .
• Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X . 6 . Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation . EMBO Reports . 3 . 2 . 171–6 . February 2002 . 11818334 . 1083965 . 10.1093/embo-reports/kvf024 .
• Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA . 6 . The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway . Oncogene . 21 . 22 . 3507–16 . May 2002 . 12032852 . 10.1038/sj.onc.1205437 . 9964634 .
• Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J . 6 . Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) . Oncogene . 21 . 19 . 3003–10 . May 2002 . 12082530 . 10.1038/sj.onc.1205390 . 20004395 .
• Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ . Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1 . The Journal of Biological Chemistry . 277 . 36 . 32413–6 . September 2002 . 12119282 . 10.1074/jbc.C200311200 . free .

Notes and References

1. Web site: Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis).
2. Ghosh S, Leaton LA, Farr L, Barfield A, Moonah S . Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function . Scientific Reports . 8 . 1 . 10241 . July 2018 . 29980718 . 6035221 . 10.1038/s41598-018-28625-1 . 2018NatSR...810241G .
3. Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J . 6 . Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 . Nature . 408 . 6809 . 211–6 . November 2000 . 11089976 . 10.1038/35041591 . 2000Natur.408..211K . 205010648 .
4. Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F . 6 . Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway . FASEB Journal . 16 . 1 . 90–2 . January 2002 . 11709497 . 10.1096/fj.01-0506fje . free . 7006611 .
5. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A . 6 . The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators . Oncogene . 18 . 22 . 3316–23 . June 1999 . 10362352 . 10.1038/sj.onc.1202717 . 2356435 .
6. Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J . 6 . Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) . Oncogene . 21 . 19 . 3003–10 . May 2002 . 12082530 . 10.1038/sj.onc.1205390 . 20004395 .
7. Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH . Psoriasin interacts with Jab1 and influences breast cancer progression . Cancer Research . 63 . 8 . 1954–61 . April 2003 . 12702588 .
8. Claret FX, Hibi M, Dhut S, Toda T, Karin M . A new group of conserved coactivators that increase the specificity of AP-1 transcription factors . Nature . 383 . 6599 . 453–7 . October 1996 . 8837781 . 10.1038/383453a0 . 1996Natur.383..453C . 4353893 .