COP9 signalosome complex subunit 3 explained

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.^{[1] [2]} It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[3]

See also

• Signalosome

Further reading

• Wolf DA, Zhou C, Wee S . The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? . Nat. Cell Biol. . 5 . 12 . 1029–33 . 2004 . 14647295 . 10.1038/ncb1203-1029 . 37458780 .
• van Dartel M, Hulsebos TJ . Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. . Cancer Genet. Cytogenet. . 153 . 1 . 77–80 . 2004 . 15325100 . 10.1016/j.cancergencyto.2004.03.007 .
• Wei N, Tsuge T, Serino G . The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. . Curr. Biol. . 8 . 16 . 919–22 . 1998 . 9707402 . 10.1016/S0960-9822(07)00372-7 . 13873982 . etal. free . 1998CBio....8..919W .
• Bianchi E, Denti S, Granata A . Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. . Nature . 404 . 6778 . 617–21 . 2000 . 10766246 . 10.1038/35007098 . 2000Natur.404..617B . 4384395 . etal.
• Tsuge T, Matsui M, Wei N . The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. . J. Mol. Biol. . 305 . 1 . 1–9 . 2001 . 11114242 . 10.1006/jmbi.2000.4288 .
• Bech-Otschir D, Kraft R, Huang X . COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system . EMBO J. . 20 . 7 . 1630–9 . 2001 . 11285227 . 10.1093/emboj/20.7.1630 . 145508 . etal.
• Lyapina S, Cope G, Shevchenko A . Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome . Science . 292 . 5520 . 1382–5 . 2001 . 11337588 . 10.1126/science.1059780 . 2001Sci...292.1382L . 14224920 . etal.
• Hong X, Xu L, Li X . CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation . FEBS Lett. . 499 . 1–2 . 133–6 . 2001 . 11418127 . 10.1016/S0014-5793(01)02535-2 . 85296851 . etal. free .
• Bi W, Yan J, Stankiewicz P . Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse . Genome Res. . 12 . 5 . 713–28 . 2002 . 11997338 . 10.1101/gr.73702 . 186594 . etal.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P . Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome . FEBS Lett. . 527 . 1–3 . 15–21 . 2002 . 12220626 . 10.1016/S0014-5793(02)03147-2 . 39308598 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Petersen HH, Hilpert J, Militz D . Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule . J. Cell Sci. . 116 . Pt 3 . 453–61 . 2003 . 12508107 . 10.1242/jcs.00243 . etal. free .
• Serino G, Su H, Peng Z . Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex . Plant Cell . 15 . 3 . 719–31 . 2003 . 12615944 . 10.1105/tpc.009092 . 150025 . etal.
• Yuryev A, Wennogle LP . Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis . Genomics . 81 . 2 . 112–25 . 2003 . 12620389 . 10.1016/S0888-7543(02)00008-3 .
• Uhle S, Medalia O, Waldron R . Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome . EMBO J. . 22 . 6 . 1302–12 . 2003 . 12628923 . 10.1093/emboj/cdg127 . 151059 . etal.
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Groisman R, Polanowska J, Kuraoka I . The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage . Cell . 113 . 3 . 357–67 . 2003 . 12732143 . 10.1016/S0092-8674(03)00316-7 . 11639677 . etal. free .
• Henriksen J, Aagesen TH, Maelandsmo GM . Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation . Oncogene . 22 . 34 . 5358–61 . 2003 . 12917637 . 10.1038/sj.onc.1206671 . etal. free .

Notes and References

1. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W . A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits . FASEB J . 12 . 6 . 469–78 . Apr 1998 . 9535219 . 10.1096/fasebj.12.6.469. free . 25424324 .
2. Potocki L, Chen KS, Lupski JR . Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2 . Genomics . 57 . 1 . 180–2 . Jun 1999 . 10191102 . 10.1006/geno.1998.5748 .
3. Web site: Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis).