COPG2 explained

Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene.^{[1] [2] [3]}

Interactions

COPG2 has been shown to interact with Dopamine receptor D1^[4] and COPB1.^{[5] [6]}

Further reading

• Pelham HR, Rothman JE . The debate about transport in the Golgi--two sides of the same coin? . Cell . 102 . 6 . 713–9 . 2000 . 11030615 . 10.1016/S0092-8674(00)00060-X . 18044044 . free .
• Waters MG, Serafini T, Rothman JE . 'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. . Nature . 349 . 6306 . 248–51 . 1991 . 1898986 . 10.1038/349248a0 . 1991Natur.349..248W . 4342145 .
• Lowe M, Kreis TE . In vivo assembly of coatomer, the COP-I coat precursor. . J. Biol. Chem. . 271 . 48 . 30725–30 . 1997 . 8940050 . 10.1074/jbc.271.48.30725 . free .
• Harter C, Wieland FT . A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 20 . 11649–54 . 1998 . 9751720 . 21695 . 10.1073/pnas.95.20.11649 . 1998PNAS...9511649H . free .
• Zhao L, Helms JB, Brunner J, Wieland FT . GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. . J. Biol. Chem. . 274 . 20 . 14198–203 . 1999 . 10318838 . 10.1074/jbc.274.20.14198 . free .
• Eugster A, Frigerio G, Dale M, Duden R . COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. . EMBO J. . 19 . 15 . 3905–17 . 2000 . 10921873 . 306616 . 10.1093/emboj/19.15.3905 .
• Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K . Identification and characterization of novel isoforms of COP I subunits. . J. Biochem. . 128 . 5 . 793–801 . 2001 . 11056392 . 10.1093/oxfordjournals.jbchem.a022817 .
• Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K . Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system. . Biochem. Biophys. Res. Commun. . 284 . 4 . 1083–9 . 2001 . 11409905 . 10.1006/bbrc.2001.5081 .
• Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P . Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum. . J. Biol. Chem. . 277 . 21 . 18266–71 . 2002 . 11884415 . 10.1074/jbc.M201388200 . free .
• Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY . Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus. . Eur. J. Cell Biol. . 81 . 2 . 77–85 . 2002 . 11893085 . 10.1078/0171-9335-00222 .
• Bonora E, Bacchelli E, Levy ER, Blasi F, Marlow A, Monaco AP, Maestrini E . Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. . Mol. Psychiatry . 7 . 3 . 289–301 . 2002 . 11920156 . 10.1038/sj.mp.4001004 . free .
• Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ . Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. . Cancer Immun. . 1 . 4 . 2003 . 12747765 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Blagitko N, Schulz U, Schinzel AA, Ropers HH, Kalscheuer VM . gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome . Hum Mol Genet . 8 . 13 . 2387–96 . Jan 2000 . 10556286 . 10.1093/hmg/8.13.2387 . free .
2. Yamasaki K, Hayashida S, Miura K, Masuzaki H, Ishimaru T, Niikawa N, Kishino T . The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting . Genomics . 68 . 3 . 330–5 . Nov 2000 . 10995575 . 10.1006/geno.2000.6265 .
3. Web site: Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2.
4. Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY . Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus . Eur. J. Cell Biol. . 81 . 2 . 77–85 . Feb 2002 . 11893085 . 10.1078/0171-9335-00222 .
5. Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K . Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system . Biochem. Biophys. Res. Commun. . 284 . 4 . 1083–9 . Jun 2001 . 11409905 . 10.1006/bbrc.2001.5081 .
6. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K . Identification and characterization of novel isoforms of COP I subunits. . J Biochem . 128 . 5 . 793–801 . 2000 . 11056392 . 10.1093/oxfordjournals.jbchem.a022817 .